Recombinant Rat cGMP-dependent protein kinase 2 (Prkg2)

1. Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a low affinity for cGMP, did not. PMID: 28057484
2. We conclude that cGKII controls the homeostatic balance of vesicle exocytosis and endocytosis in synaptic boutons of rat cerebellar granule cells. PMID: 24966379
3. Which in turn activates cGKII and induces the phosphorylation of GluA1. PMID: 23545413
4. Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway. PMID: 22203739
5. Inhibition of cGMP-dependent protein kinase II by its own splice isoform PMID: 12054676
6. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form PMID: 12764134
7. PKG II activity in zona glomerulosa cells is important for maintaining basal aldosterone production PMID: 12775716
8. confirmed that BRIN-BD11 cells (and human islets) express all three known isoforms of PKG (PKG-Ialpha, -Ibeta and II) and provide data suggesting that a transcription-dependent pathway of programmed cell death is involved in the actions of cGMP PMID: 14960318
9. Protein kinase G type II activation may define a critical control point for temporal progression into the daytime domain by acting on the positive arm of the transcriptional/translational feedback loop. PMID: 15312652
10. role of cGKII as a molecular switch, coupling the cessation of proliferation and the start of hypertrophic differentiation of chondrocytes through attenuation of Sox9 function PMID: 15466490
11. eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin on growth and proliferation of hepatoma cells PMID: 15582712
12. While nNOS and cGKI mRNA levels steadily increased during development, cGKII mRNA showed a different behaviour pattern, with similar levels observed on postnatal days 7 and 14 and increased levels noted on postnatal day 21. PMID: 15763176
13. cGMP and cGK II regulate the translocation of CFTR to the apical membrane in rat jejunum PMID: 15872007
14. the NO-PKG pathway inhibits AGE-induced proliferation by suppressing activation of JAK2-STAT5 and cyclin D1/cdk4 and induction of p21Waf1/Cip1 PMID: 15958724
15. Protein kinase G regulation of interleukin 6 promoter signaling pathway largely prevented fluid shear stress-induced increases of IL-6 mRNA in osteosarcoma cells. PMID: 17341596
16. a subset of phosphorylation sites is modulated, in a cGMP-PKG-specific manner, in intact HEK cells heterologously expressing Cav1.2 alpha(1c) and beta(2a) subunits PMID: 17626895
17. confirmed mutation in Prkg2 is a valuable model for studying dwarfism and longitudinal growth traits PMID: 19149413

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KEGG: rno:25523

STRING: 10116.ENSRNOP00000003237

UniGene: Rn.87721