Recombinant Saccharomyces cerevisiae Heat shock factor protein (HSF1), partial

1. we show here that a predicted low-complexity interacting region in the disordered C-terminus of the stress response master regulator heat shock factor 1 (Hsf1) protein corresponds to a cryptic amyloid region able to self-assemble into fibrillary structures resembling those found in neurodegenerative disorders PMID: 29734798
2. Here the authors show that in budding yeast, Hsf1 basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 activity. PMID: 27831465
3. Yeast chaperone gene expression is an essential housekeeping mechanism and provides a roadmap for defining the function of HSF1 as a driver of oncogenesis. PMID: 27320198
4. A characteristic residence time for non-specific interactions of HSF1 transcription factor with chromatin PMID: 27566148
5. Studies suggest that heat shock factor 1 (Hsf1) controls a set of chaperone protein genes devoted to restoring protein-folding homeostasis in heat shock response. PMID: 27502399
6. regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA PMID: 26209979
7. finding show that regulation of the Hsf1 S608 phosphorylation status by reciprocal actions of CK2 and Ppt1 might play an important role to determine Hsf1 sensitivity towards ethanol stress PMID: 24894977
8. Data indicate that rapamycin inhibition of heat shock transcription factor (Hsf1) can be lost through Hsp90 heat shock protein mutation PMID: 24970820
9. Rim15 induces expression of Hsf1 target genes upon glucose depletion by both transcriptional activation and stabilization of the transcripts. PMID: 24140345
10. Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16. PMID: 23447536
11. Taken together, these data demonstrate that hyperphosphorylation of Hsf1p caused by loss of the PPT1 gene at least partly accounts for the defective stress response and high ethanol productivity of modern sake yeast strains. PMID: 22057870
12. Hsf1 is a key transcription factor of HSP90 and mitochondrial HSP genes. Expression of these target genes is necessary for resistance to proteotoxic stress. Hsf1 regulates longevity through mechanisms that are separate from Rim15. PMID: 21827755
13. Carboxy-terminal region of the yeast heat shock factor contains two domains that mediates Kin28-independent transcription. PMID: 14750950
14. changes in S. cerevisiae HSF1 transcriptional activity in response to stress might be linked to the combined effects of trehalose and elevated temperatures in modifying the overall structure of HSF1's C-terminal activation domain PMID: 15651035
15. findings establish the importance of HSF in prion initiation and strain determination and imply a similar regulatory role of mammalian HSFs in the complex etiology of prion disease PMID: 16452152
16. activates expression of PDR3, encoding a multidrug resistance (MDR) transcription factor that also directly activates RPN4 gene expression. PMID: 16556235
17. expression of stress proteins are mediated by Rsp5 and that Rsp5 primarily regulates post-translational modification of Hsf1 and Msn4 PMID: 16713599
18. These in vivo results support a new role for trehalose, where trehalose directly modifies the dynamic range of Hsf1 activity and therefore influences heat shock protein mRNA levels in response to stress. PMID: 17145780
19. The levels of Hsp90 expression affecting transcription factor regulation by Hsp90 client protein kinases also provides a mechanistic model for how heat shock factor can influence the expression of several non-hsp genes in higher organisms. PMID: 17293484
20. in response to environmental stresses, Rsp5 primarily regulates the expression of Hsf1 and Msn2/4 at the post-transcriptional level and is involved in the repair system of stress-induced abnormal proteins PMID: 18233954
21. activated Hsf1 inhibits rapamycin resistance and TOR signaling via elevated expression of specific target genes PMID: 18270585
22. Hsf1 and Msn2/4 act differentially before and after exposure to extreme temperatures to ensure cell survival and growth. PMID: 18359875

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KEGG: sce:YGL073W

STRING: 4932.YGL073W