Recombinant Saccharomyces cerevisiae Histone deacetylase RPD3 (RPD3)

1. Deletion of RPD3 prevents cells from establishing transcriptional quiescence, leading to defects in quiescence entry and shortening of chronological lifespan. PMID: 26300265
2. Data indicate that chromatin remodelers enhance Rpd3S activity by altering nucleosomal spacing. PMID: 24055344
3. An important role for Rpd3 in promoting checkpoint adaptation via deacetylation and inhibition of Rad53. PMID: 23979600
4. The Rpd3L histone deacetylase complex was required for diauxic shift-induced histone H4 and H2B deposition onto rDNA genes. PMID: 23689130
5. Rpd3 core complex could contribute to repression via a novel nucleosome stabilization function. PMID: 22177115
6. Mutation or inhibition of yeast Rpd3L or Hda1 suppressed up to 90% of CTG*CAG repeat expansions. PMID: 22363205
7. Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. PMID: 20670892
8. Rpd3 is the yeast ortholog of mammalian HDAC1. It activates transcription factor SBF. PMID: 19823669
9. Raf60 is a component of the Rpd3 histone deacetylase complex and that it is required for normal Rpd3 complex activity and repression of gene expression PMID: 16275642
10. Rpd3S plays an important role in Pol II-associated Set2 methylation of H3, providing a transcriptional memory which signals for deacetylation of open reading frames. PMID: 16286007
11. The smaller complex, Rpd3C(S), was recruited by the chromodomain of Eaf3 to nucleosomes methylated by Set2 on histone H3 lysine 36, leading to deacetylation of transcribed regions. PMID: 16286008
12. In this report, we identify by mass spectrometry and MudPIT the subunits of the Rpd3L complex, Two sequence-specific repressors, Ash1 and Ume6, were stably associated with Rpd3L PMID: 16314178
13. RPD3 plays a role in the maintenance of an rRNA gene chromatin structure(s) that allows Pol II transcription of rRNA genes. PMID: 16648483
14. Genetic experiments demonstrated that cells lacking the Rpd3S-specific subunits Eaf3 or Rco1 did not display the anti-silencing phenotype of mutations in SET2 or H3-K36. PMID: 17179083
15. data provide evidence that during anaerobiosis, the Rpd3 complex acts at the DAN1 promoter to antagonize the chromatin-mediated repression caused by Mot3 and Rox1 and that chromatin remodeling by Swi/Snf is necessary for normal expression PMID: 17210643
16. the coupled chromo and PHD domains of Rpd3S specify recognition of the methyl H3K36 mark, demonstrating the first combinatorial domain requirement within a protein complex to read a specific histone code PMID: 17510366
17. Study identified the histone deacetylase Rpd3p as an attenuator of base composition-dependent differences in chromatin status. PMID: 17577398
18. Results show that Rpd3(L) and Rpd3(S), distinct multisubunit complexes containing Rpd3 histone deacetylase, have distinct functions and the relative amounts of the 2 forms alter effectiveness of other chromatin-altering complexes, such as FACT and NuA4. PMID: 18490440
19. disruption of histone deacetylase Rpd3p results in defective boundary activity, leading to a Sir-dependent local propagation of transcriptional repression. PMID: 19372273
20. loss of Rpd3 function results in higher levels of histone H3 and H4 acetylation surrounding Rpd3-regulated origins PMID: 19417103
21. Results implicate Rpd3p as an important co-factor in the Environmental Stress Response regulatory network, and suggest the importance of histone modification in producing transient changes in gene expression triggered by stress. PMID: 19470158

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KEGG: sce:YNL330C

STRING: 4932.YNL330C