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Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein SIN3 (SIN3), partial

Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein SIN3 (SIN3), partial

Code	CSB-YP332845SVG
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP332845SVG
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP332845SVG-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP332845SVG
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP332845SVG
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

SIN3

Uniprot No.

P22579

Alternative Names

SIN3; CPE1; GAM2; RPD1; SDI1; SDS16; UME4; YOL004W; Transcriptional regulatory protein SIN3

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 has also a RPD3 independent function required for normal longevity.

Gene References into Functions

Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation. PMID: 24838945
These results show that the sin3 mutation decreases both spontaneous and UV-induced levels of levels. PMID: 25711007
investigated the regulatory contribution of subunits of Sin3 complexes and identified Pho23 as important for inositol and choline-dependent gene repression PMID: 22543816
PAH2 and PAH3 od sin3 are required for mitotic early meiotic gene repression. PMID: 20971827
Mutational analysis of the Opi1-Sin3 interaction domain (OSID) revealed that hydrophobic OSID residues L56, V59 and V67 of Opi1 are indispensable for gene repression PMID: 21104417
The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. PMID: 15141165
The Sin3/HDAC complex is involved in an array of biological and cellular processes, including cell cycle progression, genomic stability, embryonic development, and homeostasis. Review. PMID: 19505602
Sin3/Rpd3 histone deacetylase complex helps to prevent premature activation of the S phase in daughter cells. PMID: 19523118