Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot No.

P09259

Alternative Names

gE; ORF68; Envelope glycoprotein E; gE

Species

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Envelope glycoprotein that binds to the potential host cell entry receptor IDE.; In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.; The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses.

Gene References into Functions

Expression and glycan processing of VZV gE were decreased after ATG5 knockdown. PMID: 24198400
gE gene sequences revealed a novel non-synonymous mutations in the e1 and c1 epitopes. PMID: 23757839
GE/gI interaction is critical for VZV neurovirulence. PMID: 20962081
data show that the nonconserved N-terminal region of varicella-zoster virus glycoprotein E is required for VZV tropism for T cells and skin, which is necessary for its life cycle in the human host PMID: 19966293
The precursor nonglycosylated gE form (73 kDa) found in the endoplasmic reticulum binds to Insulin-degrading enzyme. PMID: 19864391
C-terminal domain of varicella-zoster virus glycoprotein E plays a role in viral replication in vitro and skin and T-cell tropism in vivo. PMID: 15507627
HSV deleted for glycoprotein E is impaired for cell-to-cell spread, and VZV gE could not complement this activity. PMID: 19233447

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Subcellular Location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein.

Protein Families

Alphaherpesvirinae glycoprotein E family

Database Links

KEGG: vg:1487709

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Recombinant Varicella-zoster virus Envelope glycoprotein E (gE), partial

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