Recombinant Human Calmodulin-1(CALM1)

In Stock
Code CSB-EP004445HU
Size $1812Purchase it in Cusabio online store
(only available for customers from the US)
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names CALM1
Uniprot No. P0DP23
Research Area Signal Transduction
Alternative Names CALM1; CALM; CAM; CAM1Calmodulin-1
Species Homo sapiens (Human)
Source E.coli
Expression Region 2-149aa
Target Protein Sequence ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 32.7 kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer Tris-based buffer,50% glycerol
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time 3-7 business days
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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 Q&A
Q:

I just want to get the information about human protein; calmodulin 1 with accession no: NP_008819 respectively. I want to order the recombinant proteins of these genes. Do you manufacture these ? If then, how much the estimated cost can be?

A:
Thanks for your inquiry. Calmodulin 1 Accession No.: NP_008819
Recombinant Human Calmodulin-1(CALM1)
CSB-YP004445HU >> Yeast
CSB-EP004445HU >> E.coli
CSB-BP004445HU >> Baculovirus
CSB-MP004445HU >> Mammalian cell
Expression Region: 2-149aa, Full Length
Tag Info: EP: N-terminal 6xH

Target Background

Function
(From Uniprot)
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.; (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.
Involvement in disease Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4); Long QT syndrome 14 (LQT14)
Subcellular Location Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Protein Families Calmodulin family
Database Links

HGNC: 1442

OMIM: 114180

KEGG: hsa:801

UniGene: Hs.282410

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