CETP Antibody

Datasheet
Code CSB-RA005267A0HU
Size US$350
Uniprot No. P11597
Image
  • IHC image of CSB-RA005267A0HU diluted at 1:115 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen A synthesized peptide derived from human CETP
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Relevance Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Cholesteryl ester transfer protein, Lipid transfer protein I, CETP
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cardiovascular
Gene Names CETP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL
Involvement in disease Hyperalphalipoproteinemia 1 (HALP1)
Subcellular Location Secreted, extracellular space
Protein Families BPI/LBP/Plunc superfamily, BPI/LBP family
Tissue Specificity Expressed by the liver and secreted in plasma.
Database Links

HGNC: 1869

OMIM: 118470

KEGG: hsa:1071

STRING: 9606.ENSP00000200676

UniGene: Hs.89538

Pathway Cholesterol metabolism

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