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| Code | CSB-RA267691A0HU |
| Size | US$210 |
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| Application | Recommended Dilution |
|---|---|
| WB | 1:500-1:5000 |
| IHC | 1:50-1:200 |
| IP | 1:200-1:1000 |
The production of the recombinant FNTB antibody depended on Single B Cell technology. There are 3 main steps in the production: 1, Isolation of single B cells. High-throughput methods could be used to obtain the efficient identification and desired specificity of B cells. 7, Single B cell antibody sequencing and cloning. In this step, the antibody gene sequence of FNTB was obtained and introduced to plasmids, which then would be transferred to mammalian cells for in vitro expression of the FNTB antibody. 3, Screening of antibodies. The target antibody was obtained in this step. And it has been validated in ELISA, WB, IHC, IP.
FNTB is a protein-coding gene that encodes the protein farnesyltransferase subunit beta. The related pathways are G-protein signaling_H-RAS regulatory pathway and G-protein signaling_RhoB regulatory pathway. According to some studies, FNTB may have the following features.
Overexpression of FNTB and activation of Ras induces hypertrophy and promotes cardiomyocyte apoptosis and autophagic cell death. The lack of FNTb interfered with the conversion of prelamin A to mature lamin A, resulting in a significant accumulation of unarylated prelamin A on Western blot.
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