Code | CSB-RA559038A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The GABRA5 monoclonal antibody's DNA sequence was inserted into the plasmid, which was subsequently transfected into the cell line for expression. The GABRA5 recombinant monoclonal antibody was produced after purification using affinity chromatography. This rabbit IgG GABRA5 recombinant antibody has been evaluated in scientific applications such as ELISA, WB, and IHC. It exclusively responds with GABRA5 from humans.
GABRA5 is abundantly expressed in the hippocampus, mainly in the extrasynaptic area of CA1 pyramidal cells, where it regulates tonic inhibitory conductance and may cause synaptic plasticity and memory impairments. GABRA5-mediated phasic inhibition via vasoactive intestinal peptide (VIP) input to interneurons is important for anxiety modulation while the GABRA5 tonic suppression through this subunit may regulate spatial learning.
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