MTDH Recombinant Monoclonal Antibody

1. These findings indicate that microRNA-30a may act as a tumor suppressor in colorectal cancer and that microRNA-30a represses cell migration and invasion by decreasing metadherin PMID: 29478367
2. High MTDH expression is associated with colorectal cancer. PMID: 30015962
3. miR-655 directly targets and downregulates MTDH mRNA expression in oral squamous cell carcinoma cells. PMID: 30015840
4. Metadherin (MTDH) was validated as a direct target gene of miR874 in retinoblastoma cells. PMID: 30015932
5. AEG-1 as a target gene of miR-216b action. PMID: 29787989
6. AEG-1 participates in the effects of miR-625-3p on thyroid cancer cells. PMID: 29558717
7. Findings provide the first evidence that the aberrant expression of miR-136 may be implicated into carcinogenesis and cancer progression of OS. Functionally, miR-136 may inhibit the proliferation, migration and invasion of OS cells via negatively regulating its target gene MTDH. PMID: 29562498
8. AEG-1 was found to be significantly associated with hypoxia in ovarian cancer by regulating the HIF-1alpha/NF-kappaB/VEGF pathway. PMID: 29770329
9. miR96 may impede the epithelial to mesenchymal transition process by downregulating AEG1 in glioblastoma cancer cells. PMID: 29257267
10. The findings demonstrated that miR-379 may play tumor-suppressing roles in glioma through downregulation of MTDH and regulation of the PTEN/AKT signaling pathway. PMID: 29286115
11. High AEG1 expression was associated with Oral Squamous Cell Carcinomas. PMID: 29286223
12. miR675 expression was downregulated in melanoma tissues and cell lines. Functional assays demonstrated that the upregulation of miR675 impaired cell proliferation and invasion in melanoma. Bioinformatics analysis, luciferase reporter assay, reverse transcriptionquantitative polymerase chain reaction and western blot analysis demonstrated that metadherin (MTDH) was a direct target of miR675 in melanoma. PMID: 29257296
13. Our findings provided evidence that AEG-1 contributed to the production of inflammatory cytokines, migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes, and underscored the importance of AEG-1 in the inflammation process of rheumatoid arthritis PMID: 28927747
14. High MTDH expression is associated with gastric cancer metastasis. PMID: 28534938
15. Knockdown of MTDH expression also upregulated PTEN and suppressed pAKT protein expression in Caki2 cells. In conclusion, the present study is the first, to the best of our knowledge, to provide evidence suggesting that miRNA30a5p suppresses tumor human renal cancer cell proliferation via the MTDH/PTEN/AKT pathway PMID: 29207012
16. These results suggested that miR216b acted as a tumor suppressor in glioma by directly targeting MTDH and that the miR216b/MTDH axis may be an effective therapeutic target for the treatment of patients with this disease PMID: 29152659
17. AEG-1 functions as a selective endoplasmic reticulum mRNA-binding protein. PMID: 29438049
18. AEG-1 may play important roles at the transcription level in malignant transformation and tumor angiogenesis in non-small cell lung cancer. PMID: 28941723
19. miR-197 expression was downregulated in gastric cancer and aberrantly expressed miR-197 may partially influence gastric cancer cell proliferation and invasion by directly targeting MTDH. PMID: 29115517
20. The findings suggest that AEG-1 promotes gastric cancer metastasis through upregulation of eIF4E-mediated MMP-9 and Twist. PMID: 28661037
21. our results indicated that miR-1297 functioned as a tumor suppressor gene in regulating the EMT and metastasis of cervical cancer (CC)via targeting of AEG-1, and may represent a novel potential therapeutic target and prognostic marker for CC PMID: 29048632
22. Data suggest that MIR1271 is down-regulated in colorectal cancer tissues and cell lines; MIR1271 appears to negatively regulate MTDH expression in colorectal cancer cells; MIR1271 also activates Wnt signaling and suppresses proliferation and invasion/movement of colorectal cancer cells. (MIR1271 = microRNA-1271; MTDH = metadherin) PMID: 29315995
23. we have identified a novel mechanism for DIM- and ring-DIM-induced protective autophagy, via induction of AEG-1 and subsequent activation of AMPK. Our findings could facilitate the development of novel drug therapies for prostate cancer that include selective autophagy inhibitors as adjuvants. PMID: 28923415
24. miR-384 and AEG-1 may serve as potential targets for the diagnosis and treatment of non-small-cell lung cancer. PMID: 28938524
25. Study confirmed that hypoxia increased MTDH expression via HIF-1alpha expression. Knockdown of MTDH expression in head and neck squamous cell carcinoma (HNSCC) cell lines interrupted hypoxiainduced metastasis and glycolysis. Furthermore, reduced MTDH expression decreased HIF-1alpha expression. These results indicated the presence of a positive feedback loop between MTDH and HIF-1alpha in HNSCC. PMID: 28901527
26. Through the analysis of the Cancer Genome Atlas (TCGA) datasets for estrogen receptor (ER)-positive endometrial and breast cancers, this study found that over 25% of all gene expression correlated with MTDH. PMID: 28627585
27. The results indicated that high MTDH expression is significantly correlated with higher mortality in breast, ovarian and cervical cancer. (Meta-analysis) PMID: 27917902
28. In-depth review of the role of AEG-1 in a diverse spectrum of diseases, from cancer to HIV-1 and aging, highlighting mechanistic processes that synergize with known AEG-1 functions and promoting the notion that AEG-1 occupies a unique niche in inflammation, mitochondrial, ER and nucleolar stress, culminating in excitotoxicity and other neurodegenerative outcomes. PMID: 27090750
29. We found that overexpression of AEG-1 in PTC was positively correlated with lymph node metastasis and MMP2/9 expression. Knockdown of AEG-1 reduced the capacity of migration and invasion through downregulation of MMP2/9 in thyroid cancer cells. Furthermore, we firstly found that AEG-1 interacted with MMP9 in thyroid cancer cells. PMID: 28731152
30. miR448 was downregulated in osteosarcoma and overexpression of miR448 inhibited cell proliferation and invasion by targeting AEG1, providing novel insights into the understanding of osteosarcoma pathogenesis. PMID: 28849015
31. Upregulation of MTDH reversed the suppression of glioma cell growth and metastasis by miR-202. PMID: 28714009
32. MTDH expression does not correlate with prognosis in the esophageal adenocarcinoma patients. PMID: 28685276
33. Knockdown of MTDH gene effectively inhibits the proliferation and metastasis of SGC7901 cells. PMID: 29089083
34. oncogenic role of AEG-1 in melanoma PMID: 28429540
35. Findings clearly demonstrate that miR-320a suppresses breast cancer metastasis by directly inhibiting MTDH expression. The present study provides a new insight into anti-oncogenic roles of miR-320a. PMID: 27229534
36. Results show that miR-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells through targeting AEG-1. PMID: 28276315
37. AEG-1 knockdown inhibits migration and invasion, as well as radiation-enhanced invasion both in vitro and in vivo I colonic cancer cells. PMID: 27835571
38. Study shows that expression of AEG-1 was significantly higher in macrophages and associated with elevated expression levels of MMP-9 in hypopharyngeal cancer. These results demonstrate that macrophage AEG-1 promotes tumor invasion through up-regulation of MMP-9 in both macrophages and cancer cells. PMID: 27793010
39. Gene expression data and in silico database analysis showed that the metadherin gene (MTDH) was a direct target of both miR-145-5p and miR-145-3p regulation and high expression of MTDH predicted poorer survival of lung squamous cell carcinoma patients. PMID: 27765924
40. Results demonstrated that AEG-1 significantly enhanced invasion capabilities of OVCAR3 ovarian cancer cells and suggested that HIF-1alpha binds to AEG-1 promoter to upregulate its expression, which was correlated with metastasis in ovarian cancer. PMID: 28401704
41. Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2. AEG-1 facilitated beta-catenin translocation into the nucleus by forming a complex with LEF1 and beta-catenin, subsequently activating Wnt signaling downstream genes. PMID: 27903708
42. miR-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin PMID: 28174206
43. High MTDH expression is associated with glioblastomas. PMID: 27923917
44. MTDH induces Epithelial-mesenchymal transition-like change and invasion of glioma via the regulation of miR-130b-competing endogenous RNAs, providing the first direct link between MTDH and miRNAs in cancer cells. PMID: 28107197
45. High MTDH expression is associated with hepatocellular carcinoma. PMID: 28184926
46. c-Jun and p300 are novel interacting partners of AEG-1 in gliomas. PMID: 27956703
47. Long noncoding RNA FTX regulated astrocyte-elevated gene-1 (AEG-1) expression through microRNA miR-342-3p. PMID: 28112756
48. Study highlights the importance of interactions among lncRNA HCP5, microRNA-139, and transcription factor RUNX1 in regulating the malignant behavior of glioma cells. HCP5 down-regulated miR-139 to up-regulate RUNX1. RUNX1 promoted AEG-1 expression, which was involved in a series of oncogenic effects in glioma cells. RUNX1 also up-regulated HCP5 expression, which formed a positive feedback loop. PMID: 27434586
49. AEG-1 is involved in miR-1297-regulated prostate cancer cell proliferation and invasion.MiR-1297 targets and inhibits AEG-1 in prostate cancer. PMID: 27746178
50. IL-8 was displayed to be capable of directly interacting with metadherin (MTDH), which in turn can up-regulate IL-8 expression. PMID: 27565732

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HGNC: 29608

OMIM: 610323

KEGG: hsa:92140

STRING: 9606.ENSP00000338235

UniGene: Hs.377155