MUC13 Recombinant Monoclonal Antibody

MUC13, a transmembrane mucin protein, plays a significant role in epithelial cell signaling and has garnered considerable research attention due to its altered expression patterns in various malignancies. Originally identified as a gene down-regulated in colon cancer, MUC13 has since been implicated in multiple oncogenic pathways, making it a valuable target for researchers investigating cancer biology and signal transduction mechanisms.

This recombinant monoclonal antibody, clone 6H10, offers the consistency and reliability that demanding research applications require. Produced using recombinant technology with a defined human IgG1 isotype, this antibody provides sequence-level reproducibility between lots, ensuring your experimental results remain comparable across extended studies. The affinity-chromatography purification process delivers a high-purity reagent ready for immediate use in your workflows.

Validation data demonstrates exceptional binding performance in ELISA applications, with EC50 values in the low nanogram per milliliter range when tested against immobilized human MUC13 protein. This high-affinity binding, confirmed across multiple protein preparations with EC50 values between 2.592 and 5.269 ng/mL, indicates robust and reproducible target recognition. The recommended working dilution range of 1:5000 to 1:50000 for ELISA provides flexibility to optimize signal-to-noise ratios according to your specific experimental conditions.

Supplied in a glycerol-based PBS buffer at pH 7.4 with Proclin 300 preservative, this antibody maintains stability when stored at -20°C or -80°C. For researchers exploring MUC13's contributions to cancer progression, epithelial barrier function, or cellular signaling networks, this recombinant antibody delivers the performance and batch-to-batch consistency essential for generating publication-quality data.