Code | CSB-RA007523A51phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
Anti-phospho-EIF2S1 (S51) antibody is a recombinant monoclonal antibody that recognizes the human EIF2S1 phosphorylated at Ser51 residue. This phospho-EIF2S1 antibody was drawn and isolated from the cell culture supernatant that cultivates the mammalian cell lines containing vectors of the human phospho-EIF2S1 (S51) monoclonal antibody gene. This anti-phospho-EIF2S1 (S51) antibody underwent affinity-chromatography purification. It can be used for ELISA, WB, IHC, and IF testing with human samples.
The phosphorylation of the EIF2S1 protein is a crucial mechanism for translation control. Phosphorylation of EIF2S1 on residue S51 results in a stable (EIF2–GDP)–EIF2B interaction, which limits the GDP–GTP exchange and prevents active EIF2 liberation, reducing translation initiation. EIF2S1 has been demonstrated to be required for tumorigenesis and progression since tumors have a higher integrated stress response (ISR) than normal tissue in tumorigenesis, during which EIF2S1 maintains efficient translation of numerous genes involved in tumorigenesis.
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