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| Code | CSB-RA020468A376phHU |
| Size | US$350 |
| Uniprot No. | O75582 |
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| Immunogen | A synthesized peptide derived from Human Phospho-RPS6KA5 (S376) |
| Species Reactivity | Human |
| Tested Applications | ELISA, IHC; Recommended dilution: IHC:1:50-1:200 |
| Relevance | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Affinity-chromatography |
| Isotype | Rabbit IgG |
| Clonality | Monoclonal |
| Alias | Ribosomal protein S6 kinase alpha-5, S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL, RPS6KA5, MSK1 |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
| Research Area | Signal Transduction |
| Gene Names | RPS6KA5 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes |
| Subcellular Location | Nucleus, Cytoplasm |
| Protein Families | Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily |
| Tissue Specificity | Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. |
| Database Links |
HGNC: 10434 OMIM: 603607 KEGG: hsa:9252 STRING: 9606.ENSP00000261991 UniGene: Hs.510225 |
| Pathway |
MAPK signaling pathway
TNF signaling pathway MAPK Erk pathway Neurotrophin signaling pathway |
RPS6KA5 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA020468GA01HU | RPS6KA5 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA144527 | RPS6KA5 (Ab-376) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA997224 | Phospho-RPS6KA5 (Ser212) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA262751 | RPS6KA5 (Ab-564) Antibody | Human | ELISA,WB |
| CSB-PA938251 | RPS6KA5 (Ab-212) Antibody | Human | ELISA,WB,IHC |
| CSB-PA000661 | Phospho-RPS6KA5 (S376) Antibody | Human,Mouse | WB,IF,ELISA |
| CSB-PA003325 | RPS6KA5 Antibody | Human,Mouse,Monkey | WB,IHC,ELISA |
| CSB-PA003326 | RPS6KA5 Antibody | Human,Mouse | WB,IHC,IF,ELISA |
| CSB-PA070268 | Phospho-RPS6KA5 (T581) Antibody | Human,Mouse | WB,IHC,IF,ELISA |
| CSB-PA070269 | Phospho-RPS6KA5 (S212) Antibody | Human,Mouse | WB,IHC,ELISA |
| CSB-PA070270 | Phospho-RPS6KA5 (S360) Antibody | Human,Mouse | IHC,IF,ELISA |
| CSB-PA070271 | RPS6KA5 Antibody | Human,Mouse | WB,IHC,ELISA |
| CSB-PA070272 | RPS6KA5 Antibody | Human,Mouse | WB,IHC,IF,ELISA |
| CSB-PA020468LC01HU | RPS6KA5 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA020468LD01HU | RPS6KA5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA020468LB01HU | RPS6KA5 Antibody, HRP conjugated | Human | ELISA |
RPS6KA5 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA020468LA01HU | RPS6KA5 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
RPS6KA5 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP020468HU CSB-EP020468HU CSB-BP020468HU CSB-MP020468HU |
Recombinant Human Ribosomal protein S6 kinase alpha-5(RPS6KA5) ,partial | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K8) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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