RBM8A Recombinant Monoclonal Antibody

1. Findings demonstrate that Y14 nucleoplasmic localization is regulated not only by the previously reported N-terminal localization signal but also by the C-terminal serine/arginine repeat-containing region through phosphorylation and MAGOH binding to Y14. PMID: 29330450
2. A direct link between Y14 and p53 expression and suggests a function for Y14 in DNA damage signaling. PMID: 28361991
3. Results demonstrated that RBM8A is highly expressed in hepatocellular carcinoma (HCC), and patients with lower RBM8A expression level had longer overall survival and progression free survival. Also, results indicate that RBM8A promotes invasion and metastasis via epithelial-mesenchymal transition signaling pathway. PMID: 28259942
4. Y14 may selectively and differentially modulate protein biosynthesis. PMID: 26887951
5. this data suggests a novel role of RBM8a in the regulation of neurodevelopment. PMID: 26094033
6. Mutations of RBM8A and TBX6 are associated with disorders of the mullerian ducts. PMID: 25813282
7. It was demonstrated that Rbm8a is an essential neurogenesis regulator in embryonic cortical development. PMID: 25948253
8. Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human tumor cells. PMID: 23970407
9. Y14 positively regulates signals for TNF-alpha-induced IL-6 production at multiple steps beyond an exon junction complex protein. PMID: 23817415
10. Y14 mutants, which are deficient in binding to Magoh, could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh PMID: 22355610
11. Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains. PMID: 23115303
12. findings show that the two regulatory SNPs result in diminished RBM8A transcription in vitro and that Y14 expression is reduced in platelets from individuals with thrombocytopenia with absent radii (TAR) PMID: 22366785
13. Y14 provides a regulatory link between pre-mRNA splicing and snRNP biogenesis. PMID: 21209085
14. conserved physical linkage in medaka and human genomes PMID: 12054603
15. Tethered function analysis shows that the Y14/hUpf3b interaction is essential for nonsense-mediated decay, while surprisingly the interaction between hUpf3b and hUpf2 is not. PMID: 12718880
16. antagonistic post-translational modifications of Y14 may be involved in the remodeling of Y14-containing mRNPs PMID: 16100109
17. The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14. PMID: 16170325
18. crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic PMID: 16931718
19. Increased TAP binding correlates with increased SF2/ASF binding, but not increased REF/Aly or Y14 binding. PMID: 18243119
20. Y14 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing the tyrosine-phosphorylation of STAT3. PMID: 18503751
21. These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14. PMID: 19254694

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HGNC: 9905

OMIM: 605313

KEGG: hsa:9939

STRING: 9606.ENSP00000333001

UniGene: Hs.591455