SEPTIN8 Recombinant Monoclonal Antibody

Septin-8 belongs to the septin family of GTP-binding proteins that play essential roles in cytokinesis, membrane dynamics, and cytoskeletal organization. As a component of septin filament complexes, SEPTIN8 contributes to cellular compartmentalization and has been implicated in neurological function, making it a valuable target for researchers investigating cytoskeletal biology, cell division mechanisms, and neurodegenerative disease pathways.

This recombinant monoclonal antibody offers the reproducibility and consistency that demanding experimental workflows require. Generated from a defined clone (17B12) and produced using recombinant technology, it eliminates the lot-to-lot variability associated with traditional hybridoma-derived antibodies, ensuring your results remain comparable across extended studies and collaborative projects.

Validation data demonstrates robust performance across multiple applications and sample types. Western blot analysis confirms detection of the expected 56 kDa band in diverse human cell lines including SH-SY5Y neuroblastoma, U-251MG glioblastoma, HeLa, K562, and COLO-205 cells, providing flexibility for various experimental models. Cross-species reactivity extends to mouse and rat brain tissue lysates, supporting translational research using rodent models. Immunohistochemistry validation in paraffin-embedded human stomach tissue confirms utility for tissue-based studies, while flow cytometry analysis in 786-O cells demonstrates clear positive signal separation, enabling quantitative single-cell investigations.

The antibody's cross-species reactivity with human, mouse, and rat samples makes it particularly well-suited for comparative studies and preclinical research. Whether investigating septin dynamics in cancer cell biology, exploring neuronal cytoskeletal architecture, or examining cell division processes, this antibody provides a reliable tool for advancing your understanding of septin-mediated cellular functions.