TCF7L1 Recombinant Monoclonal Antibody

1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534

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HGNC: 11640

OMIM: 604652

KEGG: hsa:83439

STRING: 9606.ENSP00000282111

UniGene: Hs.516297