TCF7L1 Antibody

Datasheet
Code CSB-PA884626OA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q9HCS4
Image
  • Western Blot
    Positive WB detected in: 293 whole cell lysate, U251 whole cell lysate, U87 whole cell lysate
    All lanes: TCF7L1 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 63 kDa
    Observed band size: 63 kDa
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence from Human Transcription factor 7-like 1 protein (80-99AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:2000
Relevance Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3), TCF7L1, TCF3
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names TCF7L1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Subcellular Location Nucleus
Protein Families TCF/LEF family
Tissue Specificity Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
Database Links

HGNC: 11640

OMIM: 604652

KEGG: hsa:83439

STRING: 9606.ENSP00000282111

UniGene: Hs.516297

Pathway Hippo signaling pathway
Melanogenesis
Wnt signaling pathway
Adherens junction

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