Code | CSB-RA930964A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The XPO1 recombinant monoclonal antibody is produced through four steps: firstly, the XPO1 monoclonal antibody gene is sequenced, then the gene is inserted into a plasmid vector, next the recombinant vector is introduced into a host cell line, and finally the XPO1 recombinant monoclonal antibody is purified using affinity chromatography from the cell culture supernatant. The immunogen used to produce the XPO1 monoclonal antibody is a synthesized peptide derived from human XPO1. The XPO1 recombinant monoclonal antibody is useful in ELISA and IHC applications for the detection of human XPO1 protein.
The XPO1 protein, also known as Exportin-1 or CRM1, plays a critical role in the nucleocytoplasmic transport of proteins and RNA molecules. Specifically, it mediates the export of proteins with a leucine-rich nuclear export signal (NES) from the nucleus to the cytoplasm. These NES-containing proteins are involved in a variety of cellular processes, including cell cycle regulation, DNA damage response, and apoptosis. In addition, XPO1 also exports several important RNA molecules, such as microRNAs and tRNAs, from the nucleus to the cytoplasm. Dysregulation of XPO1 activity has been implicated in various diseases, including cancer and viral infections.
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