Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
The following XPO1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
XPO1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA026221GA01HU | XPO1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA000147 | Acetyl-XPO1 (K568) Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA360041 | XPO1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA026221LA01HU | XPO1 Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA026221LB01HU | XPO1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA026221LC01HU | XPO1 Antibody, FITC conjugated |
Human | |
CSB-PA026221LD01HU | XPO1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA930964A0HU | XPO1 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
XPO1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA118350XA01DOA | XPO1 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
XPO1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA026221XA01SXV | xpo1 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
XPO1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP026221HU CSB-EP026221HU CSB-BP026221HU CSB-MP026221HU CSB-EP026221HU-B |
Recombinant Human Exportin-1 (XPO1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP026221SXV CSB-EP026221SXV CSB-BP026221SXV CSB-MP026221SXV CSB-EP026221SXV-B |
Recombinant Schizosaccharomyces pombe Exportin-1 (xpo1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP706698DKK CSB-EP706698DKK CSB-BP706698DKK CSB-MP706698DKK CSB-EP706698DKK-B |
Recombinant Dictyostelium discoideum Exportin-1 (xpo1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP750809MO CSB-EP750809MO CSB-BP750809MO CSB-MP750809MO CSB-EP750809MO-B |
Recombinant Mouse Exportin-1 (Xpo1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP802224RA CSB-EP802224RA CSB-BP802224RA CSB-MP802224RA CSB-EP802224RA-B |
Recombinant Rat Exportin-1 (Xpo1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |