CHOK1/Mouse CCR8 Stable Cell Line

1. CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. PMID: 25344933
2. Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PMID: 24714157
3. A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. PMID: 23798714
4. Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. PMID: 23747724
5. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
6. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. PMID: 22031018
7. a key regulator of Th2 cell skin recruitment during IL-5-mediated allergic inflammation PMID: 21217759
8. mediates increased responsiveness of murine eosinophils to TCA-3 PMID: 12050188
9. Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin-induced allergic airway inflammation is not critically CCR8-dependent. PMID: 12574386
10. sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence PMID: 14736884
11. IL-10 production correlates with CCR8 ligand (CCL1) expression and the appearance of CCR8+ cells in granulomatous lungs and is required for full expression of the T helper type 2 cell response to parasite antigens. PMID: 15699124
12. CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity. PMID: 16384913
13. CCR8 ligands are allotropic, binding to distinct sites within CCR8 PMID: 17023422
14. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
15. Ccr8 has a pivotal role in the progression of experimental fungal asthma. PMID: 17321573
16. Mast cell-derived CCR8- and CCL1-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID: 17641040
17. Results suggest that CCR8 plays a significant role in the pathogenesis of experimental autoimmune encephalomyelitis and probalby of multiple sclerosis. PMID: 17850582
18. CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID: 17947648

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KEGG: mmu:12776

STRING: 10090.ENSMUSP00000038473

UniGene: Mm.442098