Recombinant Arabidopsis thaliana Putative cyclic nucleotide-gated ion channel 18 (CNGC18)

Code CSB-CF878476DOA
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Source in vitro E.coli expression system
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Product Details

Target Names
CNGC18
Uniprot No.
Alternative Names
CNGC18; At5g14870; T9L3_170; Cyclic nucleotide-gated ion channel 18; Cyclic nucleotide- and calmodulin-regulated ion channel 18
Species
Arabidopsis thaliana (Mouse-ear cress)
Expression Region
1-706
Target Protein Sequence
MNKIRSLRCLLPETITSASTAASNRGSDGSQFSVLWRHQILDPDSNIVTYWNHVFLITSI LALFLDPFYFYVPYVGGPACLSIDISLAATVTFFRTVADIFHLLHIFMKFRTAFVARSSR VFGRGELVMDSREIAMRYLKTDFLIDVAAMLPLPQLVIWLVIPAATNGTANHANSTLALI VLVQYIPRSFIIFPLNQRIIKTTGFIAKTAWAGAAYNLLLYILASHVLGAMWYLSSIGRQ FSCWSNVCKKDNALRVLDCLPSFLDCKSLEQPERQYWQNVTQVLSHCDATSSTTNFKFGM FAEAFTTQVATTDFVSKYLYCLWWGLRNLSSYGQNITTSVYLGETLFCITICIFGLILFT LLIGNMQSSLQSMSVRVEEWRVKRRDTEEWMRHRQLPPELQERVRRFVQYKWLATRGVDE ESILHSLPTDLRREIQRHLCLSLVRRVPFFSQMDDQLLDAICGCLVSSLSTAGTYIFREG DPVNEMLFVIRGQIESSTTNGGRSGFFNSTTLRPGDFCGEELLTWALMPNSTLNLPSSTR SVRALSEVEAFALSAEDLKFVAHQFKRLQSKKLQHAFRYYSHQWRAWGACFVQSAWRRYK RRKLAKELSLHESSGYYYPDETGYNEEDEETREYYYGSDEEGGSMDNTNLGATILASKFA ANTRRGTNQKASSSSTGKKDGSSTSLKMPQLFKPDEPDFSIDKEDV
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cyclic nucleotide-gated ion channel required for directional pollen tube growth into the transmitting tract. Acts as a Ca(2+)-permeable divalent cation-selective channel inhibited by either lanthanum or gadolinium. Regulated by CPK32 to mediate Ca(2+) transport across the plasma membrane in response to Ca(2+) oscillation.
Gene References into Functions
  1. Data demonstrate that CNGC18 plays essential roles in pollen germination and tube growth as a Ca(2+) channel in Arabidopsis. PMID: 27322818
  2. Among 8 Ca(2+) channels, CNGC18 was the only one essential for pollen tube guidance. Its transmembrane domains are needed for this function. Point mutations R491Q or R578K resulted in abnormal Ca(2+) gradients and strong pollen tube guidance defects. PMID: 26929345
  3. Arabidopsis CNGC18 is a Ca(2)-permeable channel PMID: 24380879
  4. CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals PMID: 17726111
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein Families
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
Tissue Specificity
Expressed in pollen grains. Not detected in leaves, roots or root hairs.
Database Links

KEGG: ath:AT5G14870

STRING: 3702.AT5G14870.1

UniGene: At.31874

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