Recombinant Horse Endothelin B receptor(EDNRB)

Code CSB-CF007404HO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O62709
Storage Buffer Tris-based buffer,50% glycerol
Species Equus caballus (Horse)
Sequence EERRFPPARATPPLLGFEEIMTPPTKTSWPTGSNASVPRLSAPPQMPKAGRTAGAQRRTL PPPPCERTIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLAL GDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVAS WSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDMITADYKGSYLRICLLHPTQKTAF MQFYKNAKDWWLFSFYFCLPLAITAFFYTLETCEMLRKKSGMQIALNDHLKQRREVAKTV FCLVLVFALCWLPLHLSRILKHTLYDQNDPHRCELLSFLLVLEYIGINMASLNSCINPIA LYLVSKRFKNCFKWCLCCWCQSFEEKQSLEDKQSCLKFKANDHGYDNFRSSNKYSSS
Source in vitro E.coli expression system
Gene Names EDNRB
Protein Names Recommended name: Endothelin B receptor Short name= ET-B Short name= ET-BR Alternative name(s): Endothelin receptor non-selective type
Expression Region 27-443
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Involvement in disease Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis.
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
Database Links

KEGG: ecb:100033875

STRING: 9796.ENSECAP00000022427

UniGene: Eca.13045

Pathway Calcium signaling pathway
Melanogenesis
cGMP-PKG signaling pathway

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