EDNRB

Endothelin receptor type B (EDNRB), a G protein-coupled receptor (GPCR) also known as ET-B receptor, binds endothelins (ET-1, ET-3) to activate downstream pathways like PLC/IP3/Ca²⁺ signaling. It regulates vascular relaxation in endothelial cells and is critical for neural crest cell migration during embryonic development.
Mutations in EDNRB cause Waardenburg syndrome type IV (Waardenburg-Shah syndrome), characterized by hearing loss, pigmentary anomalies, and Hirschsprung disease. Therapeutic research includes EDNRB agonists for Hirschsprung-related gut dysfunction, while antagonists like BQ-788 are used in preclinical studies to explore vascular disorder mechanisms.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

EDNRB Antibody (CSB-PA007404LA01HU)

Validated Data

Western Blot
Positive WB detected in: Mouse heart tissue, Mouse skeletal muscle tissue
All lanes: EDNRB antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50, 49, 60 kDa
Observed band size: 50 kDa

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA007404LA01HU at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA007404LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following EDNRB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

EDNRB Antibodies

EDNRB Proteins

EDNRB Antibodies

EDNRB Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA937611	EDNRB Antibody	Human	ELISA,WB,IHC
CSB-PA093669	EDNRB Antibody	Human	ELISA,IHC
CSB-PA708179	EDNRB Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-PA460645	EDNRB Antibody	Human	WB,ELISA
CSB-PA007404LA01HU	EDNRB Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA007404LB01HU	EDNRB Antibody, HRP conjugated	Human	ELISA
CSB-PA007404LC01HU	EDNRB Antibody, FITC conjugated	Human
CSB-PA007404LD01HU	EDNRB Antibody, Biotin conjugated	Human	ELISA

EDNRB Proteins

EDNRB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP634671MOV CSB-EP634671MOV CSB-BP634671MOV CSB-MP634671MOV CSB-EP634671MOV-B	Recombinant Macaca fascicularis Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)

Code	Product Name	Source
CSB-CF856176DXJ	Recombinant Coturnix coturnix japonica Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP856176DXJ1 CSB-EP856176DXJ1 CSB-BP856176DXJ1 CSB-MP856176DXJ1 CSB-EP856176DXJ1-B	Recombinant Coturnix coturnix japonica Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-CF885629RB	Recombinant Rabbit Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP885629RB1 CSB-EP885629RB1 CSB-BP885629RB1 CSB-MP885629RB1 CSB-EP885629RB1-B	Recombinant Rabbit Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF007404BO	Recombinant Bovine Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP007404BO1 CSB-EP007404BO1 CSB-BP007404BO1 CSB-MP007404BO1 CSB-EP007404BO1-B	Recombinant Bovine Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF007404MO	Recombinant Mouse Endothelin B receptor (Ednrb)	in vitro E.coli expression system
CSB-YP007404MO1 CSB-EP007404MO1 CSB-BP007404MO1 CSB-MP007404MO1 CSB-EP007404MO1-B	Recombinant Mouse Endothelin B receptor (Ednrb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF007404DO	Recombinant Dog Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP007404DO1 CSB-EP007404DO1 CSB-BP007404DO1 CSB-MP007404DO1 CSB-EP007404DO1-B	Recombinant Dog Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF007404RA	Recombinant Rat Endothelin B receptor (Ednrb)	in vitro E.coli expression system
CSB-YP007404RA1 CSB-EP007404RA1 CSB-BP007404RA1 CSB-MP007404RA1 CSB-EP007404RA1-B	Recombinant Rat Endothelin B receptor (Ednrb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF007404PI	Recombinant Pig Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP007404PI1 CSB-EP007404PI1 CSB-BP007404PI1 CSB-MP007404PI1 CSB-EP007404PI1-B	Recombinant Pig Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-CF007404HO	Recombinant Horse Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP007404HO1 CSB-EP007404HO1 CSB-BP007404HO1 CSB-MP007404HO1 CSB-EP007404HO1-B	Recombinant Horse Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDNRB Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF007404HU	Recombinant Human Endothelin B receptor (EDNRB)	in vitro E.coli expression system
CSB-YP007404HU1 CSB-EP007404HU1 CSB-BP007404HU1 CSB-MP007404HU1 CSB-EP007404HU1-B	Recombinant Human Endothelin B receptor (EDNRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP007404HU	Recombinant Human Endothelin receptor type B (EDNRB)-VLPs	Mammalian cell

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EDNRB

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