Recombinant Human C-C chemokine receptor type 6(CCR6)

Code CSB-CF004845HUa2
Size US$3503
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names CCR6
Uniprot No. P51684
Research Area Others
Alternative Names BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; C-C chemokine receptor type 6; C-C CKR-6; CC chemokine receptor type 6; CC CKR 6; CC R6; CC-CKR-6; CCCKR6; CCR 6; CCR-6; Ccr6; CCR6_HUMAN; CD 196; CD196; CD196 antigen; Chemokine (C C motif) receptor 6; Chemokine (C C) receptor 6; Chemokine (CC motif) receptor 6; Chemokine (CC) receptor 6; Chemokine receptor 6; Chemokine receptor like 3; Chemokine receptor-like 3; CKR 6; CKR L3; CKR-L3; CKR6; CKRL3; CMKBR 6; CMKBR6; DCR 2; DCR2; DRY 6; DRY6; G protein coupled receptor 29; G-protein coupled receptor 29; GPR 29; GPR CY4; GPR-CY4; GPR29; GPRCY 4; GPRCY4; LARC receptor; Seven transmembrane receptor lymphocyte 22; STRL 22; STRL22
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Expression Region 1-374aa
Target Protein Sequence MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 58.5 kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Receptor for the C-C type chemokine CCL20
Gene References into Functions
  1. Co-culture with BD2 and BD3 led to up-regulation of CD4+ T cell proliferation after 72 h whereas, CD4+ T cell proliferation was suppressed after 96 h. On the other hand, CCR6- and CCR6+ T cell proliferation was up-regulated after 72 h. PMID: 30098283
  2. Identified a population of gut-derived TREG cells producing CCR6 and CXCR6 which are significantly reduced in inflammatory bowel disease. PMID: 29981781
  3. CCR6 facilitates tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer PMID: 29097259
  4. expression increased on B cells of systemic lupus erythematosus patients PMID: 28444576
  5. In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation. PMID: 28206670
  6. Bin1-N-BAR domains assemble into scaffolds of low long-range order that form flexible membrane tubule in the sarcolemma PMID: 27016283
  7. CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity. PMID: 29262350
  8. High expression of CCR6 is associated with cutaneous T-cell lymphoma. PMID: 26789110
  9. CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected patients. PMID: 26883727
  10. results provide a potential explanation for involvement of the CCL20-CCR6 system in the trafficking of IL-17-producing cells to degenerated IVD tissues PMID: 23823618
  11. High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation. PMID: 27018255
  12. CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer. PMID: 27149649
  13. The study suggests that a genetic interaction between DPP4 and CCR6 is involved in RA susceptibility PMID: 27587881
  14. point mutations in CCR6 can result in either a gain or loss of receptor function PMID: 27789680
  15. Rheumatoid arthritis-associated double nucleotide polymorphism in CCR6 regulates CCR6 via PARP-1. PMID: 27626929
  16. This study evaluated the role of CCL20 and CCR6 in the regulation of laryngeal neoplasms; it showed that these proteins acted on proliferation and metastasis via the p38 pathway and multiple microRNAs. PMID: 27916417
  17. CCR6 expression may be a novel biomarker for predicting clinical outcomes for gastric cancer patients. PMID: 26489425
  18. Cell migration assays showed that TNF-alpha treatment significantly increased the rate of migrated cells in those cells in which it also increased the membrane expression of CCR6 (TPC-1 and BCPAP) as compared to basal condition PMID: 26577851
  19. There were early increased plasma concentrations of CCL20 and CCR6 in patients with sepsis. CCL20 and CCR6 correlate with severity of illness in ICU patients. Levels of CCR6 predicted the length of patients' admission. PMID: 26771764
  20. High CCR6 expression is associated with Inflammatory Bowel Disease. PMID: 26536229
  21. Tregs of unexplained recurrent miscarriage patients was significantly lower than that in controls. CCL20-CCR6 could drive immune activity of CD4(+)FOXP3(+) Tregs, followed by their migration to the feto-maternal microenvironment PMID: 26345847
  22. AEG-1 mediates CCL20/CCR6-induced EMT development via both Erk1/2 and Akt signaling pathway in cervical cancer, which indicates that CCL20/CCR6-AEG-1-EMT pathway could be suggested as a useful target to affect the progression of cervical cancer. PMID: 26156805
  23. The involvement of cell surface nucleolin in the initiation of CCR6 signaling in human hepatocellular carcinoma.Expression of nucleolin and CCR6 correlates with overall survival in hepatocellular carcinoma patients. PMID: 25698534
  24. Late-onset cytomegalovirus infection was preceded by an immune phenotype characterized by increased CCR6 expression on bulk CD4(+) T cells following solid organ transplant. PMID: 25690781
  25. The data reviewed suggest the necessity of evaluation of other blood redox-balance and nitric oxide in psoriasis should with additional investigations to targeting CCR6 rs3093024 in the genetic susceptibility of psoriasis. PMID: 25879557
  26. the current data demonstrate a genetic association between CCR6 variants and susceptibility to lupus nephritis PMID: 26138531
  27. Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway PMID: 25768730
  28. High CCR6 expression is associated with colon cancer. PMID: 24866282
  29. Leukocytes expressing CCR6 are present in the ovary immediately prior to ovulation. PMID: 26125463
  30. The data of this study suggested that CCR6 expression, which shows an increase in both moderatesevere and mild Alaheimer disease patients, is related to the pathological process underlying Alzaheimer disease. PMID: 25408215
  31. CCR6 SNPs are a risk factor for presence of anti-topoisomerase I antibodies in systemic sclerosis. PMID: 26314374
  32. CCL20 cooperated with CCR6 could recruit T regulatory cells to tumor sites, and chemotherapy medicine docetaxel could decrease the expression of CCL20. PMID: 25661365
  33. hBD-3 stimulates IL-37 expression through CCR6 in keratinocytes PMID: 25541254
  34. RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population PMID: 25928629
  35. PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells. PMID: 25833398
  36. CKR-L3 with other minor coreceptors may contribute to HIV and SIV pathogenesis including dissemination, trafficking and latency especially when major coreceptors become compromised. PMID: 24980635
  37. These findings support the hypothesis that CCR6 up-regulation stimulated by IL-17 may play an active role in colorectal cancer cell migration. PMID: 25201147
  38. The tumor expression of CCR6 plays a critical role in colorectal cancer metastasis. PMID: 24979261
  39. CCR6/CCL20 biological axis increased the capacity of proliferation and adhesion, as well as the chemotactic migration and the level of cytokines related to degraded extracellular matrix. PMID: 24743888
  40. genetic and biological role of the C-C chemokine ligand CCL20 and the C-C chemokine receptor CCR6in rheumatoid arthritis, is discussed.[review] PMID: 24394994
  41. CCR6 is highly expressed in thyroid cancer cells.CCR6 promotes the invasion and migration of thyroid cancer cells via NF-kappa B signaling-induced MMP-3 production. PMID: 24984269
  42. CCR6+ naive precursors contain a predetermined reservoir to replenish IL-17-secreting cells and may have implications in balancing the Th17 effector and IL-17+ Treg compartments that are perturbed during HIV infection. PMID: 24958901
  43. CCR6 protein level was higher in hepatocellular carcinoma (HCC) than in adjacent noncancerous tissues. CCR6 expression correlated with multicentricity and vascular invasion. CCR6 expression was an independent prognostic factor for overall survival. PMID: 24634224
  44. CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. PMID: 24559209
  45. DPP4, CDK5RAP2, and CCR6 are risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. PMID: 24782177
  46. interfering with IL-1beta and IL-12 signaling in Th17 cells during inflammation may be a promising therapeutic approach to reduce their differentiation into "pathogenic" CCR6+ CXCR3+ Th1/17 cells in patients with autoimmune diseases. PMID: 24890729
  47. Dendritic and T cells in psoriasis express CCL20 and CCR6 as part of the pathology. PMID: 24401998
  48. High CCR6/CCR7 expression and Foxp3 positive T regulatory cell number are positively related to the progression of laryngeal squamous cell carcinoma PMID: 23835793
  49. A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis. PMID: 22527137
  50. Chemokine receptor CCR6-dependent accumulation of gammadelta T cells in injured liver restricts hepatic inflammation and fibrosis. PMID: 23959575
  51. MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma. PMID: 24385540
  52. CCR6 and CXCR2 were higher in the colorectal metastasis group than in the non-metastasis group, but there was no difference between the lung and liver metastasis subgroups. CXCR4 was not different between the metastasis and non-metastasis groups. PMID: 23758411
  53. This study was designed to determine the association of CCR6 and FGFR10P (tag)single nucleotide polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, in two independent Chinese Han populations. PMID: 23935994
  54. The results of this study establish CCR6 as a new susceptibility factor for antitopoisomerase-positive SSc, confirming the notion that systemic sclerosis and rheumatoid arthritis could conceivably share autoimmune risk alleles. PMID: 23983073
  55. results suggest that plasmin generated in inflamed tissues might elicit production of chemokine CCL20 by human macrophages leading to the recruitment of CCR6 positive Th17 cells to the inflammatory sites PMID: 23681234
  56. some of the physiological reactions mediated by CCR6 ligands in male reproduction extend beyond a pro-inflammatory response and might find application in clinical reproduction and/or contraception. PMID: 23765988
  57. results strongly suggest an association between CCL20/CCR6 expression and the induction of colorectal adenoma, colorectal adenocarcinoma and the development of colorectal liver metastases PMID: 23790181
  58. Results suggest that the CCR6 rs3093024 polymorphism may not play a relevant role in the giant cell arteritis pathophysiology PMID: 23306142
  59. Our data suggest for the first time that CCL20 and CCR6 might play an important role in the regulation of aggressiveness in human gliomas PMID: 22926920
  60. CXCR3 promotes recruitment of Th17 cells from the blood into the liver in both human and murine liver injury. Their subsequent positioning near bile ducts is dependent on CCR6 and cholangiocyte-secreted CCL20. PMID: 22796894
  61. Increased expression of CCR6 is found in memory T-cells from Wegener's granulomatosis patients with polyangiitis. PMID: 22490506
  62. CD161high CCR6+ gammadelta T cells contribute to the inflammatory process in the central nervous system of multiple sclerosis patients. PMID: 23599932
  63. study found a significant association between the genotype of CCR6 (rs3093024) and the susceptibility to rheumatoid arthritis in a Taiwanese population PMID: 22859539
  64. Review: Studies using the ApoE knockout mouse model have recently implicated chemokine receptor Ccr6 and its ligand Ccl20 as a nonredundant ligand-receptor pair in atherosclerosis. PMID: 22732549
  65. Data indicate that JAK2 rs10758669 and CCR6 rs2301436 did not prove to be significant risk factors for both Crohn's disease (CD) and ulcerative colitis (UC). PMID: 22269120
  66. CCL20/CCR6 may play an important role in the pathogenesis of rheumatoid arthritis by assembling the molecular and cellular components orchestrating synovitis. PMID: 21724701
  67. CCR6 polymorphism was a risk factor for rheumatoid arthritis among asian females but a protective factor among asian males. PMID: 22092173
  68. The CCL20-CCR6 axis mediates the migration of circulating Tregs into tumor microenvironment, which in turn results in tumor progression and poor prognosis in HCC patients. PMID: 21935436
  69. CCR6 SNPs can be used to predict clinical outcome, and that polymorphisms in the CCR6 gene may influence T cell-mediated immune reactions after HSCT. PMID: 21763254
  70. The role of the CCL20/CCR6/IL-17 axis in non-small-cell-lung-cancer tumor growth, was investigated. PMID: 21949768
  71. A novel population of transgenic, CCR6-expressing, gammadelta-low expressing T cells is recruited to epidermal keratinocytes upon treatment with IL-23. PMID: 21984702
  72. unlike blood plasmacytoid dendritic cells (pDCs), a subset of tonsil pDCs express functional CCR6 and CCR10, and their respective ligands CCL20 and CCL27 are detected in inflamed epithelia PMID: 21937703
  73. The tested CCR6 gene polymorphisms are not associated with the susceptibility to Behcet's disease in the tested Chinese Han populations. PMID: 21873313
  74. Data show that both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy PMID: 21912453
  75. The relative expression levels of CCR6 and CCR7 mRNA in tumor tissues with lymphatic metastases were significantly lower than those without lymph node metastases. PMID: 21092675
  76. CCR6 and CCR7 are expressed in metastatic lymph nodes and PBMC, and might play a role in laryngeal squamous cell carcinoma development. PMID: 21261017
  77. These results suggest a contribution of CCR6 expression on tumor cells and CCL19-expressing DC in breast cancer dissemination. PMID: 21624121
  78. Data show that integrin beta7 and CCR6 identify four distinct stages of memory CD4+ T cell differentiation. PMID: 21398606
  79. CCL20 induces MUC5AC mucin production via CCR6- and tumor necrosis factor (TNF)-alpha-converting enzyme (TACE)-dependent epidermal growth factor receptor (EGFR) activation in human airway epithelial (NCI-H292) cells. PMID: 21300824
  80. we have identified a noncoding region of the human CCR6 gene with methylation-sensitive transcriptional activity in CCR6(+) T cells that controls stable CCR6 expression via epigenetic mechanisms. PMID: 21228329
  81. Down-regulation of CCR6 is associated with adenocarcinoma of the lung. PMID: 20872189
  82. Transgenic CCR6 expression characterizes a Foxp3-positive regulatory T-cell population that can be induced in mucosal tissues, that produces IL-10, and that traffics to inflamed colonic tissue to suppress ongoing inflammation of the colon. PMID: 20720211
  83. Under inflammatory conditions, mesenchymal stem cells mediate adhesion of T helper (Th)17 cells via CCR6 and exert anti-inflammatory effects through induction of a T cell regulatory phenotype in these cells. PMID: 20511548
  84. CCL20 and CCR6 play a role in the development and progression of pancreatic cancer and may constitute potential targets for novel treatment strategies. PMID: 20459729
  85. We studied a unique cohort of 21 primary lung cancers with matched adrenal metastases for the expression of CX3CR1, CXCR4, CCR6, and CCR7 PMID: 20439195
  86. CCR6 is expressed at higher levels in plasmacytoid dendritic cells from melanoma patients compared to healthy controls. CCR6 may have a role in these cells' migration to tumor sites where CCL20 is produced. PMID: 20220766
  87. The CCR6DNP genotype was correlated with the expression level of CCR6 and was associated with the presence of interleukin-17 (IL-17) in the sera of subjects with rheumatoid arthritis PMID: 20453841
  88. human beta-defensin (hBD)2 and 3 are chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner PMID: 20483750
  89. Data show that recombinant mBD4:Ig and hBD2:Ig fusion proteins retained potent antimicrobial activity against Gram-negative and Gram-positive bacteria, and that these fusion proteins showed specific binding to CCR6-expressing cells. PMID: 20068036
  90. CCR6 positive memory T cells producea suppressive IL-10 but not IL-2 upon stimulation with autologous immature dendritic cells. PMID: 20194631
  91. Isoleucine/leucine in the N-terminal alpha-helix region of this beta-defensin is essential for CCR6-mediated chemotaxis. PMID: 20022113
  92. CCR6 ligands inhibit HIV by inducing APOBEC3G. PMID: 20023216
  93. CCR6 mediates induction APOBEC3G expression, resulting in inhibition of HIV infection in highly susceptible CCR6+ cells PMID: 20023216
  94. Data show that number of peripheral Th17 lymphocytes, expression of CCR6 on Th cells, and ex vivo IL-23, anti-CD3 and anti-CD28 induced production of IL-22 by PBMC were significantly elevated in asthmatic patients. PMID: 19811428
  95. CCR6 preferentially attracts memory B cells and becomes an efficacious B-cell receptor following cellular activation, acquiring an enhanced function due to changes in the responsiveness of downstream signaling pathways. PMID: 11994436
  96. CCR6, appears to have an important role in the selective recruitment of T cells, in the context of periodontal inflammation. PMID: 12067311
  97. Mutating the four extracellular cysteines reveals their differing roles in receptor trafficking, ligand binding, and signaling. PMID: 12081481
  98. Clustering of CCR6 and coassociation with critical integrins such as CD18/beta2 integrin serve to strengthen adhesion between T cells and activated dermal microvascular endothelial cells in vitro. PMID: 12193700
  99. characterized the expression of CCR6 on B cells and B-cell non-Hodgkin's lymphomas PMID: 12514792
  100. Coincident expression of CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis may contribute to their accumulation in nonlymphoid organs such as skin and bone PMID: 12642342

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Subcellular Location Cell membrane, Multi-pass membrane protein, Cell surface
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein
Database Links

HGNC: 1607

OMIM: 601835

KEGG: hsa:1235

STRING: 9606.ENSP00000339393

UniGene: Hs.46468

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