CCR6 plays a pivotal role in cellular signaling as a member of the G protein-coupled receptor family. It comprises seven transmembrane domains, two cytoplasmic regions, and an extracellular domain, enabling it to bind its ligands and transduce signals. CCR6 ligands include CCL20 (also known as MIP-3α), which directs the migration of specific immune cell types to particular tissues or organs. In addition to immune cell migration, CCR6 also plays a role in various physiological and pathological processes such as inflammation, tumor metastasis, and neural development. CCR6 mediates its biological effects through the activation of multiple signaling pathways, primarily including G protein-coupled receptor signaling (via G protein activation) and non-G protein-coupled receptor signaling (via activation of mitogen-activated protein kinase (MAPK) signaling, among others). The activation of these signaling pathways can lead to cellular migration, proliferation, differentiation, and other biological responses.
Recombinant Human C-C chemokine receptor type 6(CCR6)-VLPs (Active)
Validated Data
CSB-MP004845HU is detected by Mouse anti-6*His monoclonal antibody. The two bands respectively correspond to monomer, Homodimer.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR6 at 10μg/mL can bind Anti-CCR6 recombinant antibody (CSB-RA004845MA1HU), the EC50 is 44.79-56.10 ng/mL.VLPs (CSB-MP3838) is negative control.
The following CCR6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCR6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004845EA01HU | CCR6 Antibody |
Human | ELISA, WB |
CSB-PA004845EC01HU | CCR6 Antibody, FITC conjugated |
Human | |
CSB-PA943255 | CCR6 Antibody |
Human | ELISA,WB,IHC |
CSB-PA244343 | CCR6 Antibody |
Human | ELISA,IHC |
CSB-RA004845MA1HU | CCR6 Recombinant Monoclonal Antibody |
Human | ELISA |
CSB-RA004845MA2HU | CCR6 Recombinant Monoclonal Antibody |
Human | Non-conjugated |
CCR6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004845MO | Recombinant Mouse C-C chemokine receptor type 6 (Ccr6) |
in vitro E.coli expression system |
CSB-YP004845MO1 CSB-EP004845MO1 CSB-BP004845MO1 CSB-MP004845MO1 CSB-EP004845MO1-B |
Recombinant Mouse C-C chemokine receptor type 6 (Ccr6), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004845HU | Recombinant Human C-C chemokine receptor type 6 (CCR6) |
in vitro E.coli expression system |
CSB-YP004845HU1 CSB-BP004845HU1 CSB-MP004845HU1 CSB-EP004845HU1-B |
Recombinant Human C-C chemokine receptor type 6 (CCR6), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004845HUa2 | Recombinant Human C-C chemokine receptor type 6 (CCR6) |
in vitro E.coli expression system |
CSB-EP004845HU1 | Recombinant Human C-C chemokine receptor type 6 (CCR6), partial |
E.coli |
CSB-MP004845HU | Recombinant Human C-C chemokine receptor type 6(CCR6)-VLPs (Active) |
Mammalian cell |