Recombinant Human Cytochrome c oxidase subunit 3 (MT-CO3)

1. There was a significant association of cytochrome c oxidase III 15bp deletion with human male infertility. PMID: 26712170
2. this is the first study showing to demonstrate that aa72-117 in HBx is the key region for binding with COXIII. PMID: 25483779
3. A novel COIII gene m.9588G>A mutation was found in the mtDNA sperm's in all asthenozoospermic patients and was absent in the normozoospermic and in fertile men. PMID: 24550096
4. novel heteroplasmic mutation m.9276G>C in the mitochondrial COIII gene, detected in mtDNA extracted from leukocytes of a mother and her two daughters indicating that this mutation is maternally transmitted PMID: 25701779
5. Lack of Cox3 limits the biosynthesis of COX but does not alter the structure of the enzyme. PMID: 25588698
6. A novel heteroplasmic missense mitochondrial mutation (m.9387 G>A) in COXIII gene found in 3 asthenospermic patients from Tunisia. PMID: 23645088
7. A novel COX III subunit single base pair deletion is associated with a high number (45%) of COX-negative muscle fibers in a patient with severe rhabdomyolysis but no family history of neuromuscular disorder. PMID: 21163656
8. a novel heteroplasmic missense mitochondrial mutation at nucleotide 9478 in COX3 gene in patients with Leigh syndrome PMID: 20525945
9. The total mtDNA major arc deletion level was greater than the common deletion level in COX 3-deficient spiral ganglion cells. PMID: 20085441
10. Data show that both normal and mutant alpha-synuclein specifically interact with the mitochondrial complex IV enzyme, cytochrome C oxidase (COX). PMID: 12059041
11. Mutations in mtDNA-encoded cytochrome c oxidase subunit III genes causing isolated myopathy or severe encephalomyopathy. PMID: 16288875
12. a MELAS syndrome Korean family harbor homoplasmic missense mutation in mitochondrial genom, which confers pathogenicity (Phe251Leu) PMID: 18587274

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HGNC: 7422

OMIM: 220110

KEGG: hsa:4514

STRING: 9606.ENSP00000354982