Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1(HS6ST1)

Code CSB-CF010756HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O60243
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW
Source in vitro E.coli expression system
Gene Names HS6ST1
Protein Names Recommended name: Heparan-sulfate 6-O-sulfotransferase 1 Short name= HS6ST-1 EC= 2.8.2.-
Expression Region 1-411
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
Involvement in disease Hypogonadotropic hypogonadism 15 with or without anosmia (HH15)
Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families Sulfotransferase 6 family
Tissue Specificity Expressed in fetal brain.
Database Links

HGNC: 5201

OMIM: 604846

KEGG: hsa:9394

STRING: 9606.ENSP00000259241

UniGene: Hs.512841

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