HS6ST1 Antibody

Code CSB-PA010756LA01HU
Size US$166
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  • Western blot
    All lanes: HS6ST1 antibody at 2 μg/ml + Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 49, 30 kDa
    Observed band size: 49 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA010756LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HS6ST1 Polyclonal antibody
Uniprot No.
Target Names
HS6ST1
Alternative Names
HS6ST1; HS6ST; Heparan-sulfate 6-O-sulfotransferase 1; HS6ST-1
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 protein (3-133AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HS6ST1 Antibody (Product code: CSB-PA010756LA01HU) is Non-conjugated. For HS6ST1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010756LB01HU HS6ST1 Antibody, HRP conjugated ELISA
FITC CSB-PA010756LC01HU HS6ST1 Antibody, FITC conjugated
Biotin CSB-PA010756LD01HU HS6ST1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
Gene References into Functions
  1. RT-PCR analysis showed that the overall transcriptional activity of the main Heparan Sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) was decreased by 1.5-2-fold in Grade II-III glioma. PMID: 29104277
  2. HS6ST-1 and HS6ST-2 have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF signaling and subsequent expression of angiogenic cytokines by cancer cells PMID: 24563483
  3. Hs6st1 and Hs2st generate conditions conducive to corpus callosum development. PMID: 24501377
  4. idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development PMID: 21700882
  5. we have characterized HS6ST-2 and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity. PMID: 12492399

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Involvement in disease
Hypogonadotropic hypogonadism 15 with or without anosmia (HH15)
Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Sulfotransferase 6 family
Tissue Specificity
Expressed in fetal brain.
Database Links

HGNC: 5201

OMIM: 604846

KEGG: hsa:9394

STRING: 9606.ENSP00000259241

UniGene: Hs.512841

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