Recombinant Human Lysophosphatidic acid receptor 4(LPAR4)

Code CSB-CF013050HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q99677
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVS LFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLT NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTN VNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQI GTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLA TLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNN GGELMLESTF
Source in vitro E.coli expression system
Gene Names LPAR4
Protein Names Recommended name: Lysophosphatidic acid receptor 4 Short name= LPA receptor 4 Short name= LPA-4 Alternative name(s): G-protein coupled receptor 23 P2Y purinoceptor 9 Short name= P2Y9 P2Y5-like receptor Purinergic r
Expression Region 1-370
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.
Database Links

HGNC: 4478

OMIM: 300086

KEGG: hsa:2846

STRING: 9606.ENSP00000362398

UniGene: Hs.522701

Pathway PI3K-Akt signaling pathway
Oxidative Phosphorylation
Phospholipase D signaling pathway
Rap1 signaling pathway

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