Recombinant Mouse Cadherin-5 (Cdh5)

1. endothelial VE-cadherin is involved in the reconstruction of the blood-brain barrier following ischemic stroke PMID: 29205257
2. TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling. PMID: 27643869
3. These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their transendothelial migration. PMID: 28701303
4. Galphas depletion blocks the S1PR1-activation induced VE-cadherin stabilization at junctions. PMID: 26674379
5. Rab11a/Rab11 family-interacting protein 2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity. PMID: 26663395
6. These findings together demonstrate the essential role of KDM4A and KDM4C in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 and VE-cadherin promoters, respectively PMID: 26120059
7. In the absence of Tie-2, VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP. PMID: 26642851
8. identification of novel components of the adherens junction complex, and introduction of a novel molecular mechanism through which the VE-cadherin complex controls YAP transcriptional activity PMID: 26668327
9. Endotoxin challenge initiates interrelated changes in microvessel Cx43, VE-cadherin, and microvessel permeability, with changes in Cx43 temporally leading the other responses. PMID: 26163513
10. Mutating Y731 in the cytoplasmic tail of VE-cadherin, known to selectively affect leukocyte diapedesis, but not the induction of vascular permeability, attenuates bleeding. PMID: 26169941
11. mRNA of HIF-2alpha and Ets-1 were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin PMID: 25626335
12. iPS cell-derived Flk1(+)VE-cadherin(+) cells expressing the Er71 are as angiogenic as mES cell-derived cells and incorporate into CD31(+) neovessels. PMID: 24386480
13. VE-cadherin tyrosine phosphorylation at Y685 is a physiological and hormonally regulated process in female reproductive organs. PMID: 24858855
14. Conclude that the site Y685 in VE-cadherin is involved in the physiological regulation of capillary permeability in mouse ovary/uterus. PMID: 24858856
15. Findings support the importance of adhesion molecules (VE-cadherin and CD31), survivin, and Ajuba in modulating the Hippo pathway, which regulates, in part, proliferation and survival in hemangioendotheliomas. PMID: 25266662
16. role of eNOS and VE-cadherin in angiopoietin-1 regulation of microvascular reactivity and protection of the microcirculation during acute endothelial dysfunction PMID: 24407281
17. Tyr685 and Tyr731 of VE-cadherin distinctly and selectively regulate the induction of vascular permeability or leukocyte extravasation PMID: 24487320
18. We suggest that lymphocyte binding to vascular cell adhesion molecule 1 triggers a signaling process that enables a VE-PTP substrate to dissociate VE-PTP from VE-cadherin, thereby facilitating efficient transmigration. PMID: 23908467
19. We found that activation of Notch1 in the endothelial compartment in VE-cadherin expressing cells resulted in the absence of intra-aortic clusters and defects in fetal liver hematopoiesis. PMID: 22851140
20. Phosphorylation of vascular endothelial cadherin contributes to a dynamic state of adherens junctions. PMID: 23169049
21. This correlates with inhibition of vascular endothelial growth factor-A (VEGF-A)-induced signaling and stabilization of vascular endothelial (VE)-cadherin localization at endothelial junctions. PMID: 22975327
22. VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking. PMID: 22606350
23. Data suggest that VE-cadherin controls vascular permeability and limits fibrogenesis after unilateral ureteral obstruction (UUO). PMID: 22126970
24. Angiogenesis is stimulated by mini-TyrRS and inhibited by mini-TrpRS by VE-cadherin signaling events. PMID: 21442253
25. The cadherin Cdh5 (Vecad) maintains high expression variability only during fetal development, while the integrin subunit Itga5 (alpha5) increases its variability after 14.5 dpc. PMID: 22276210
26. These results establish the junctional route as the main pathway for extravasating leukocytes in several tissues, for which the plasticity of the cadherin-5-alpha-catenin complex is central for the leukocyte diapedesis mechanism. PMID: 21857650
27. CRSBP-1 ligands induce disruption of VE-cadherin-mediated intercellular adhesion and opening of intercellular junctions in lymphatic endothelial cell. PMID: 21444752
28. By demonstrating that Wt1(-KTS) protein trans-activates an enhancer element in the first intron we identified CDH5 as a novel target gene of Wt1. PMID: 20811903
29. key role of KLF4 in the regulation of VE-cadherin expression at the level of the adheren junctions and in the acquisition of VE-cadherin-mediated endothelial barrier function PMID: 20724706
30. The VE-Cad complex with pulmonary adenoma resistance 3 (Par3) protein highlights how the unique molecular architecture of par3-PDZ3 can accommodate both canonical and distal interaction modes. PMID: 20047332
31. VEC may influence the constitutive organization of the actin cytoskeleton. PMID: 11950930
32. Data show that vascular endothelial protein tyrosine phosphatase (VE-PTP) is a transmembrane binding partner of VE-cadherin that reduces the tyrosine phosphorylation of VE-cadherin and cell layer permeability. PMID: 12234928
33. Data suggest that ADAM15, whose expression may be driven by VE-cadherin, may be a component of adherens junctions and play a role in endothelial functions mediated by these cell contacts. PMID: 12243749
34. VE-cadherin-beta-catenin complex participates in contact inhibition of VEGF signaling PMID: 12771128
35. Data show that sustained activation of MAPK/ERKs results in disruption of VE-cadherin-mediated cell-cell adhesion, down-regulation of PECAM-1 expression, and enhanced cell migration in microvascular endothelial cells. PMID: 12938162
36. Cdh5 expression and clustering maintain low levels of survivin in endothelial cells. PMID: 15215174
37. de novo blood vessel formation up to when a vascular epithelium forms is not dependent on VE-cadherin and VE-cadherin, whose expression is up-regulated following vascular epithelialization, is required to prevent the disassembly of nascent blood vessels. PMID: 15604224
38. transcription is controlled by the hypothalamo-pituitary axis PMID: 15691883
39. analysis of endothelial cell-specific gene expression of the 5' flanking region and the 5' half of the first intron of the VE-cadherin gene PMID: 15746076
40. virtually all HSC activity from embryonic day 13.5 (E13.5) fetal liver was CD144+. CD144 expression declined on E16.5 fetal liver HSCs and was absent from adult bone marrow HSCs PMID: 15831702
41. MIP-1beta is overexpressed, and VE-cadherin is underexpressed in heart transplant allografts compared with isografts PMID: 15897346
42. downregulation of VE-cadherin in endothelial tumors may have important consequences for tumor growth and bleeding complications PMID: 15968386
43. PECAM-1, vascular endothelial cell cadherin, and VEGFR2 comprise a mechanosensory complex: together these receptors are sufficient to confer responsiveness to fluid shear stress in heterologous cells PMID: 16163360
44. A new ischemia-induced neovascularization mechanism involving VE-cadherin, re-expressed VE-cadherin mediating cell adhesion. PMID: 16543497
45. HIF-2alpha cooperates with the Ets-1 transcription factor for activation of the VE-cadherin promoter and that this synergy is dependent on the binding of Ets-1 to DNA. PMID: 17563748
46. Vascular sprout formation entails tissue deformations and Cdh5-dependent cell-autonomous motility. PMID: 18062955
47. VE-cadherin has a role in modulating c-Src activation in VEGF signaling PMID: 18180305
48. Measured changes in VE-cadherin after cardiac arrest in mouse lung in relation to warm ischemia time and lung injury. PMID: 18281348
49. VE-cadherin promotes breast cancer progression via transforming growth factor beta signaling PMID: 18316602
50. These data indicate that VE-cadherin is a positive and endothelial cell-specific regulator of TGF-beta signalling. PMID: 18337748

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KEGG: mmu:12562

STRING: 10090.ENSMUSP00000034339

UniGene: Mm.21767