Recombinant Mouse Calcium release-activated calcium channel protein 1 (Orai1)

1. activation of TRPC1-based SOCs through a STIM1-activated PLCbeta1 pathway are likely to occur independently of Orai1 proteins PMID: 28301277
2. SGK1 influences migration of VSMC by transcriptional regulation of Ca2+ channel Orai1 expression, an effect requiring SGK1-dependent activation of transcription factor NF-B after arterial injury. PMID: 28203685
3. the declined Orai1 expression, at least partly, contributes to the downregulated Ca(2+) entry during lymphocyte excitation, providing an important mechanism for T lymphocyte malfunction in diabetes. PMID: 29654766
4. SOCE was largely diminished in cells where STIM1 and/or ORAI1 had been silenced by small interfering (si)RNA. We conclude that extracellular ATP activates SOCE in white adipocytes, an effect predominantly mediated by STIM1 and ORAI1. PMID: 29335300
5. Study shows that STIM1 and ORAI1 promotes membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and ORAI1 co-localize with cortactin. PMID: 28341841
6. Results show that Orai1 binds to the PRY-SPRY region of MG53 and co-localizes with MG53 in the plasma membrane in skeletal muscle which enhances extracellular Ca2+ entry via Orai1 by store-operated Ca(2+) entry mechanism. PMID: 27841305
7. Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2+ entry (SOCE)-associated genes (STIM1, ORAI1 and TRPC1). PMID: 28656279
8. Our study demonstrates that Orai1-Ca(2+)-calcineurin-NFATc4 signaling is an essential inflammatory pathway required for TNFalpha-induced endothelial cell activation and vascular inflammation. Therefore, Orai1 may be a potential therapeutic target for treatment of inflammatory diseases. PMID: 29223400
9. Store-operated calcium entry via Orai1 in mesangial cells negatively regulates the TGF-beta1/Smad3 signaling pathway. PMID: 28637791
10. Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content PMID: 27587568
11. Mouse embryos deficient in Orai1, Klf2, or Klf4 showed a significantly reduced lymphatic density and impaired lymphatic development. PMID: 28167653
12. Store operated calcium entry negatively regulates the Smad1 signaling pathway and inhibits Col IV protein production in glomerular mesangial cells. PMID: 28298362
13. F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 currents and tyrosinase activity and significantly inhibited UV-induced melanogenesis PMID: 27712859
14. mice lacking acinar Orai1 exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death. PMID: 28273482
15. these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2 channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2+) entry due to co-activation of Orai1- and TRPC1-dependent store-operated Ca(2+) channels and L-type Ca(2+) channels. PMID: 27535226
16. reveal that Orai1(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development PMID: 26969191
17. In Dicer-deficient mice Orai1 was down-regulated at mRNA and protein level in CD4+ T cells. PMID: 27607422
18. results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses. PMID: 26956485
19. Orai1-dependent Ca(2+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 Ca(2+) channel a potential therapeutic target against atherosclerosis. PMID: 26916730
20. strong expression during the ameloblast secretory stage PMID: 26178077
21. alternative translation initiation of the Orai1 message produces at least three types of Ca(2+) channels with distinct signaling and regulatory properties. PMID: 26221052
22. Orai1 and STIM1 have roles in inhibiting matrix protein expression PMID: 25788524
23. SOCE blockers or ablation of STIM1, STIM2, or Orai1 severely impaired nucleotide-induced migration and phagocytosis in microglia. PMID: 25471906
24. Our data establish Orai1 as key signal mediator of C5aR activation, contributing to inflammation PMID: 25912155
25. Orai1 store-operated calcium channels have an essential role in lactation PMID: 25902527
26. TRPC6 activity can occur independently of the physical interaction with Orai1 PMID: 24520961
27. Data show that increased activity of STIM1-Orai1 complex inducing enhanced Ca(2+) influx is a disease determinant in muscular dystrophy. PMID: 24556214
28. STIM1, STIM2, and CRAC channel function play distinct but synergistic roles in CD4+ and CD8+ T cells during antiviral immunity PMID: 25157823
29. The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy PMID: 24135962
30. Data indicate that STIM1 is involved in both early neural differentiation of ES cells and survival of early differentiated ES cells independent of Orai1-mediated SOCE. PMID: 24424349
31. These studies indicate a critical role for Orai1-mediated SOCE in lacrimal gland signalling and function. PMID: 24297846
32. Store-operated Ca(2+) entry was lost in embryonic and adult mouse neural progenitor cells from transgenic mice lacking Orai1 or STIM1 and in knock-in mice expressing the loss-of-function Orai1 mutant R93W. PMID: 24990931
33. Inhibition of Orai1 induces skin atrophy and decreases epidermal proliferation in mice PMID: 24317393
34. Lactation is associated with the enhancement of basal Ca2+ influx that appears to occur through the calcium channel Orai1. PMID: 24359162
35. The AMPK alpha1 sensitive Ca2+ entry is abrogated by Orai1 blocker 2-APB. PMID: 24080823
36. T cells expressing ORAI1-DN lacked TCR activation induced [Ca(2+)]i elevation, yet arrested motility similar to control T cells in vitro. PMID: 23939929
37. Orai1 protein is mainly confined to the basal layer of epidermis where it plays a critical role to control keratinocyte proliferation and polarized motility. PMID: 24277812
38. Data indicate that the Ca(2+) release-activated Ca(2+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+) entry in a concentration-dependent manner. PMID: 23878235
39. ORAI1 is the main calcium entry mechanism during oxidative glutamate toxicity, suggesting that SOCE inhibition might be a valuable tool in the treatment of diseases associated with increased oxidative stress. PMID: 23348584
40. Our data indicates that upregulation of the Orai1-mediated SOCE pathway and an overloaded SR Ca(2+) store contributes to the disrupted Ca(2+) homeostasis in mdx muscles and is linked to elevated proteolytic activity PMID: 23185465
41. Orai1 function is essential for T cell homing to lymph nodes. PMID: 23455504
42. The Orai1-mediated Store-operated Ca(2+) entry plays a crucial role in the mineralization of osteoblasts by regulating expression of bone matrix protein. PMID: 23122304
43. Orai-1 protein level is greatly upregulated in airway smooth muscle cells from asthmatic mice. PMID: 23014880
44. The data provided direct evidence that TRPC1 and Orai1 channels mediate capacitative calcium entry through activation of STIM1 in acute hypoxic mouse pulmonary arterial smooth muscle cells. PMID: 23034388
45. Micro-CT showed reduced cortical ossification and thinned trabeculae in Orai1(-/-) animals compared with controls; bone deposition was markedly decreased in the knockout mice. This suggests a previously unrecognized role for Orai1 within osteoblasts. PMID: 22546867
46. intracellular alkalinization inhibits SERCA activity, activating store-operated channels (SOCs) of Orai1 and Stim1, leading to increased Ca(2+) influx PMID: 22384096
47. ORAI1 is involved in the Ca(2+) entry pathway in the mature oocyte. PMID: 22053056
48. Downregulation of Orai1 expression in the airway, adminestering recombinant lentivirus vectors that encoded shRNA against ORAI1, alleviated symptoms of allergic rhinitis in mice. PMID: 22170034
49. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1. PMID: 22389502
50. Results indicate that Orai1 plays a critical role in the differentiation and function of osteoclasts, by regulating activation of the transcription factor NFATc1. PMID: 22198385

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KEGG: mmu:109305

STRING: 10090.ENSMUSP00000058169

UniGene: Mm.218582