Recombinant Mouse Gastrin-releasing peptide receptor(Grpr)

Code CSB-CF009943MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Grpr
Uniprot No. P21729
Alternative Names GrprGastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor
Species Mus musculus (Mouse)
Expression Region 1-384
Target Protein Sequence MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNI TLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFI QLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFS DLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQ SAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSML HFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMT SFKSTNPSATFSLINRNICHEGYV
Protein Length Full length protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for gastrin-releasing peptide (GRP)
Gene References into Functions
  1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
  2. ablating GRP receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially PMID: 26855425
  3. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. PMID: 25209280
  4. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
  5. The present results suggest that BB2 receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. PMID: 23778077
  6. spinal GRPr and NMBr independently drive itch neurotransmission in mice. PMID: 23826298
  7. GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex PMID: 22312434
  8. Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders. PMID: 22203955
  9. The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization PMID: 22000021
  10. We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-knockout mice PMID: 21254899
  11. GRP-R-deficient mice showed no significant different in risk assessment behavior of conventional anxiwety parameters, so GRP-R may not impact this anxiety or emotional behavior. PMID: 11803457
  12. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
  13. GRPR has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
  14. GRPR gene expression was detected predominantly in utero in lung development PMID: 12959933
  15. MCH was significantly enhanced in BRS-3-deficient mice but not in GRP-R-deficient mice PMID: 14988239
  16. GRP-R immunoreactivity was observed in the lateral (LA), central, and basolateral amygdaloid (BLA) nuclei and NTS, which are important regions for memory performance. PMID: 15680955
  17. Changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting. PMID: 16519669
  18. GRPR may represent the first molecule that is dedicated to mediating the itch sensation in the dorsal horn of the spinal cord PMID: 17653196
  19. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
  20. These findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. PMID: 18753628

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Detected in pancreas and brain (PubMed:1671171, PubMed:9345264). Detected in suprachaismatic nucleus neurons (PubMed:28280205). Detected in neurons in the dorsal horn of the spinal cord (PubMed:17653196). Detected in inhibitory GABAergic interneurons in t
Database Links

KEGG: mmu:14829

STRING: 10090.ENSMUSP00000033730

UniGene: Mm.4687

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