Recombinant Mouse Inward rectifier potassium channel 2 (Kcnj2)

1. Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue increased the channel responses to phosphatidylinositol diphosphate (PIP2) through increased binding affinity and faster activation kinetics, and the deactivation kinetics decreased upon PIP2 inhibition. PMID: 26520451
2. Our results support the concept that endothelial cell Kir2 channels boost vasodilatory signals that are generated by Ca(2+) -dependent activation of IK and SK channels. PMID: 26840527
3. Results suggest that a promyogenic cell adhesion molecule Cdo signaling is critical for Inward rectifier potassium channel Kir2.1 activities in the induction of myogenic differentiation. PMID: 27380411
4. The data suggest that microglial Kir2.1 channels may represent novel therapeutic targets to inhibit excessive reactive oxygen species production by primed microglia in brain pathology. PMID: 27598576
5. Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel. PMID: 27699887
6. Suggest that Kir2.1 channels, in part, account for hyperpolarization and associated absence of tone in urinary bladder arterioles. PMID: 28148533
7. This finding represents the first functional evidence for a significant role of the dystrophin-associated protein complex in the regulation of Kir2.x channels. PMID: 27560040
8. Intracellular Mg(2+) and SPM therefore may have a synergistic action on the pore-blocking effect, presumably via prohibition of the outward exit of the higher-affinity blocking SPM by the lower-affinity Mg(2+). PMID: 26869275
9. Consistent with a role of the K(+) current in amplifying the sensory response, entry of protons through the Zn(2+)-sensitive conductance produces a transient block of the KIR2.1 current. PMID: 26627720
10. Mouse neutrophils express functional Kir2.1 channels from bone marrow and liver. PMID: 25472961
11. A184R mutation in the inner end of the bundle crossing region of Kir2.1 not only abolishes the inward rectifying features of spermine block but also tends to close the channel pore. PMID: 24633623
12. the present work demonstrates that a functional Kir2.1-like channel is expressed in lactating mouse mammary secretory cells. PMID: 24259419
13. Kir2.1 mRNA levels were downregulated by LPS, and to a lesser extent by IL-4/IL-13. PMID: 24249731
14. Report pentamidine analogue which specifically blocks cardiac KIR2.1 channel, lengthening action potential duration. PMID: 23625347
15. The total Kcnj2 (gene for the Kir2.1 potassium channel) mRNA was reduced in Huntington disease skeletal muscle. PMID: 23671115
16. miR-26 controls the expression of KCNJ2 and may have a role in atrial fibrillation PMID: 23543060
17. Stronger expressions of SCN5a, SCN1b and Kir2.1 were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes. PMID: 22348965
18. The data of this study suggested that Kir2.1 is required for I(K1) in type II utricle hair cells. PMID: 22496522
19. An inwardly rectifying K+ channel is required for patterning. PMID: 22949619
20. These results demonstrate that three functional ion channel currents, I(KCa), I(Cl.vol), and I(Kir), are heterogeneously present in 3T3-L1 preadipocytes. I(KCa) and I(Cl.vol) participate in the regulation of cell proliferation. PMID: 21732368
21. These results suggested that the blocking kinetics depends on driving force to produce driving force-dependent inward rectification when the equilibrium potential for potassium is altered by changing external potassium. PMID: 20962011
22. HL-1 cardiac myocytes express a current that is characteristic of cardiac inward rectifier K(+) channels, and express K(ir)2.1 mRNA. PMID: 20568224
23. Data suggest that the earlier-than-normal expression of Kir2.1 in hair cells inhibits their spontaneous activity required for spiral ganglion neuron survival and neurite growth. PMID: 20045730
24. Modulation of the inward rectifier potassium channel IRK1 by the Ras signaling pathway PMID: 11809752
25. AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampus. PMID: 11906215
26. K+ influxes from neuronal "sources" into glial cells are mediated mainly by strongly rectifying Kir channels (Kir2.1), expressed in glial membrane sites where direct glia-neuron interactions occur. PMID: 12203395
27. Single and double mutations in the pore-forming M1-M2 segment of Kir2.1 characterize conductance states of the channel and demonstrate a novel functional role for M1-M2 as a critical structural determinant in adjustments of pore conformations. PMID: 12369836
28. These findings can be accounted for by a model in which the negative charges at E224, E299 and D172 act in a concerted manner to coordinate the surface charge reduction and open channel components of polyamine block. PMID: 12740427
29. significant role of IK1 in cardiac excitability is consistent with adverse effects of IK1 upregulation on cardiac electrical activity. PMID: 15271672
30. Kv1.3 and Kir2.1 expression was impaired in brain during cancer cachexia PMID: 15304346
31. a short sequence located in the N-terminal part of the linker between the two transmembrane segments is essential for high-affinity inhibition by TPN and variability in the region underlies the variation of TPN affinities among eukaryotic Kir channels PMID: 15311931
32. These observations implicate E224 and E299 as allosteric modulators of a fast gate, located at the bundle crossing or below in Kir2.1 channels PMID: 15459242
33. E153 contributes to the conductance properties of Kir2.1 channels by acting as a surface charge PMID: 15824191
34. changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in Huntington disease PMID: 15880743
35. The molecular interfaces formed between PSD95 PDZ domains and Kir2.1 tail involve regions outside the previously identified binding motif and may be important for additional channel-specific interactions with associating PDZ-containing proteins. PMID: 17437338
36. mouse heart upregulation of IK1 is proarrhythmic PMID: 17546530
37. Functional Kir2.1 ion channel currents are present in mouse bone marrow mesenchymal stem cells. PMID: 17699636
38. We speculate that restricted dynamics & preferential Kir2.1 binding to PDZ2 are features that enable SAP97 to function as a scaffold protein, allowing other proteins to bind to other 2 PDZ domains in sufficient proximity to yield productive channelosomes. PMID: 18004877
39. The interaction of PIP(2) with only one Kir2.1 subunit is sufficient for the channel to become available and to open to its full conductance state. Interaction with additional subunits exerts positive cooperativity at multiple levels. PMID: 18276733
40. Results imply that Kir2.1 channels in astrocytes may be involved in buffering K(+) against accumulated extracellular K(+) caused by neuronal hyperexcitability under phathophysiological conditions. PMID: 18319624
41. we describe the transcription profiles of the four HCN genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse. PMID: 19421833

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KEGG: mmu:16518

STRING: 10090.ENSMUSP00000037192

UniGene: Mm.4951