KCNJ2

The gene KCNJ2 encodes for the inward-rectifier potassium channel subfamily J member 2, also known as Kir2.1. This protein functions as a voltage-gated potassium channel, regulating the membrane potential in various cell types, including cardiac myocytes. Its mechanism involves the selective permeability of potassium ions, which is crucial for maintaining resting membrane potential and contributing to action potential repolarization. KCNJ2 is involved in several signaling pathways, including those related to cardiac function and neuronal survival. Mutations in KCNJ2 are associated with Andersen-Tawil syndrome, a condition characterized by periodic paralysis, cardiac arrhythmias, and developmental abnormalities. In terms of drug development, KCNJ2 inhibition is being explored as a therapeutic target for conditions like traumatic brain injury and neurodegenerative diseases.