Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1)

1. Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells. PMID: 28437001
2. Although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine. PMID: 28437578
3. This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. PMID: 26014037
4. Cytotoxic KLRG1-expressed CD8 effector cells and defective T regulatory cells cause murine autoimmune cholangitis. PMID: 24556277
5. KLRG1(+) iNKT cells coexpressing CD49d and granzyme A persisted for several months and displayed a potent secondary response to cognate antigen. PMID: 25118276
6. Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. PMID: 24162776
7. Data indicate that increments of CD8 + effector memory T cells in human and mouse chronic lymphocytic leukemia (CLL)(Emu-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset. PMID: 24022692
8. Despite their differences, KLRG1+ and KLRG1- Treg cells proved similarly potent in suppressing experimental autoimmune encephalomyelitis. PMID: 23436224
9. KLRG1(-/-) mice had a significant survival extension after Mycobacterium tuberculosis infection compared to wild-type controls, and maintained a significantly lower level of pulmonary bacterial load throughout chronic infection. PMID: 23340310
10. CD8+ T cells lacking Id2 do not generate a robust terminally differentiated killer cell lectin-like receptor G1 (KLRG1hi) effector population, but display a cell-surface phenotype and cytokine profile consistent with memory precursors. PMID: 23325888
11. The lower inhibitory capacity of mKLRG1 compared with hKLRG1 can thus be rationalized by a decreased proportion of dimeric entities, which can be pinpointed to a single amino acid. PMID: 22684915
12. KLRG1high-expressiong CD8 T cells isolated from the lung during the peak of influenza infection could long survive in vitro and participate in a recall response to influenza virus infection upon adoptive transfer. PMID: 23089397
13. The KLRG1+NKG2A+ positive phenotype correlates with protective efficacy for generating effector and proliferative memory responses from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection. PMID: 21346231
14. Interleukin-2-activated natural killer cells interact with tumor necrosis factor-alpha-stimulated endothelial cells to induce their proliferation and promote angiogenesis through a mechanism involving alpha4beta7 integrin and KLRG1. PMID: 20971926
15. KLRG1 does not play a deterministic role in the generation & functional characteristics of NK & T-cell subsets. The inhibitory potential of KLRG1 in mice is weak. Strong activation signals during viral infections may override the inhibitory signal. PMID: 20201037
16. Both pathogenic and nonpathogenic in vivo activation of NK cells induces cell surface expression of KLRG1, while in vitro studies show that engagement of the receptor on a transfected NK cell line inhibits cytokine production and cell-mediated cytoxicity. PMID: 11884419
17. Expression of KLRG1 on CD8+ and CD4+ T cell subsets isolated from naive animals appears to be largely restricted to T cells that exhibit a memory phenotype. PMID: 12794113
18. MafA is differentially expressed in beta-cells where it regulates insulin gene expression. PMID: 14765989
19. repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells PMID: 16140789
20. KLRG1 ligation by E-, N-, or R-cadherins may regulate the cytotoxicity of killer cells to prevent damage to tissues expressing cadherins. PMID: 16461340
21. Upon phosphorylation of the immunoreceptor tyrosine-based inhibitory motif tyrosine, KLRG1 recruits both SHIP-1 and SHP-2 but not SHP-1. PMID: 17307799
22. NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo. PMID: 17404256
23. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. PMID: 18424713
24. KLRG1 formed multimeric protein complexes in T cells in addition to the previously described mono- and dimeric molecules PMID: 19009530
25. KLRG1 recognizes the N-terminal homodimeric interface of domain 1 of E-cadherin and binds only the monomeric form of E-cadherin to inhibit the immune response. PMID: 19654330
26. our results provide novel insights on how KLRG1 and E-cadherin interactions are integrated to differentially regulate not only KLRG1(+) cells, but also E-cadherin-expressing cells, such as dendritic cells. PMID: 19855082

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KEGG: mmu:50928

STRING: 10090.ENSMUSP00000032207

UniGene: Mm.20434