Recombinant Mouse Relaxin receptor 1(Rxfp1)

Code CSB-CF764847MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Rxfp1
Uniprot No. Q6R6I7
Alternative Names Rxfp1; Gm1018; Lgr7; Relaxin receptor 1; Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1
Species Mus musculus (Mouse)
Expression Region 1-758
Target Protein Sequence MTSGPFFFCIFIIGKYFTLGSAQDVSCPLGSFPCGNMSRCLPQLLHCNGVDDCGNRADED HCGDNNGWSLQLDKYFANYYKLASTNSFEAETSECLVGSVPMHCLCRDLELDCDEANLRA VPSVSSNVTVMSLQRNFIRTLPPNGFRKYHELQKLCLQNNRIHSVSVSAFRGLRSLTKLY LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYGLNSLILLVLMNNALTRLPDK PLCQHMPRLHWLDFEGNRIHNLRNLTFISCNNLTVLVMRKNKINYLNEHAFTHLQKLDEL DLGSNKIENLPPNIFKDLKELSQLNISYNPIQKIEVNQFDCLAKLKSLSLEGIEISNIQQ RMFRPLINLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITC FGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGVYLFVIGAFDLKFRGEYNKHAQPWM ESVHCQFMGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCLRPRKCRTITVLIFIWIIGF IVAFAPLGNKEFFKNYYGTNGVCFPLHSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYG SMFYSVHQSSVTVTEIQKQVKKEVVLAKRFFFIVFTDALCWIPIFILKFLSLLQVEIPDS ITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWHNYRQRRSVDRKETQKAYAPSFIW VEMWPLQEMSSGFMKPGAFTDPCDLSLVSQSSRLNSYS
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Gene References into Functions
  1. No differences were found in RXFP1 expression related to aging. PMID: 26109313
  2. Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus. PMID: 26360621
  3. relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy PMID: 25715795
  4. maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction PMID: 22984576
  5. H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID: 21229994
  6. The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors. PMID: 20861284
  7. Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt signaling in prostate cancer. PMID: 20503398
  8. mouse and rat LGR7 are the relaxin receptors in these species PMID: 15566402
  9. Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands PMID: 15956680
  10. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling PMID: 15956683
  11. gene expression profiling of Lgr7 in the adult mouse brain PMID: 15956708
  12. expression of lgr7 in mouse brain membranes and neurons PMID: 15956710
  13. Inhibition of androgen-independent growth was also achieved by blocking expression of LGR7, the cognate receptor of H2 relaxin PMID: 16434975
  14. LGR7-expressing cells in the stroma are both necessary and sufficient for relaxin to promote proliferation and inhibit apoptosis in both stromal and epithelial cells of cervix and vagina. PMID: 18218691
  15. RXFP1 is involved in mediating relaxin's effects on airway fibrosis during homeostasis but not during inflammation-induced fibrosis associated with chronic allergic airways disease. PMID: 18974264
  16. Data show that cardiac RXFP1 expression increased in hearts of transgenic mice with cardiomyocyte-restricted overexpression of alpha1A-AR, alpha1B-AR, or beta2-AR, demonstrating distinct regulation by adrenergic signaling of cardiac RXFP1 expression PMID: 19416204

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Subcellular Location Cell membrane; Multi-pass membrane protein.
Protein Families G-protein coupled receptor 1 family
Database Links

KEGG: mmu:381489

STRING: 10090.ENSMUSP00000077611

UniGene: Mm.331086

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