Recombinant Mouse Serine protease HTRA2, mitochondrial(Htra2)

Code CSB-CF881313MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q9JIY5
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Source in vitro E.coli expression system
Gene Names Htra2
Protein Names Recommended name: Serine protease HTRA2, mitochondrial EC= Alternative name(s): High temperature requirement protein A2 Short name= HtrA2 Omi stress-regulated endoprotease Serine protease 25 Serine proteinase O
Expression Region 134-458
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity).
Subcellular Location Mitochondrion intermembrane space, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Database Links

KEGG: mmu:64704

STRING: 10090.ENSMUSP00000087073

UniGene: Mm.21880

Pathway Apoptosis

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