Recombinant Mouse Zinc transporter ZIP14 (Slc39a14)

1. This study concludes that SLC39A14 is essential for efficient Mn uptake by the liver and pancreas, and its deficiency results in impaired Mn excretion and accumulation of the metal in other tissues. PMID: 29437953
2. Data indicate SLC39A14 (ZIP14) as a regulator of bone homeostasis, and that manipulating ZIP14 might be a therapeutic strategy for bone diseases. PMID: 29621230
3. Zip14 activity is needed for adaptation to endoplasmic reticulum stress in liver. PMID: 28673968
4. Data suggest that most if not all tissues use ZIP8 and ZIP14A/ZIP14B (alternative splicing products) for Zn(2+) uptake, some tissues under basal conditions and others more so when inflammatory stressors are present (as in endotoxemia); collectively, this might lead to substantial alterations in plasma Zn(2+) levels due to Zn(2+) redistribution not just in liver but across many vital organs. PMID: 24728862
5. the inflammation-responsive zinc transporter ZIP14 has phenotypic effects that are amplified with aging PMID: 27647172
6. ZIP14 is essential for manganese elimination via the gastrointestinal tract, and a lack of ZIP14 results in manganese accumulation in critical tissues such as the brain PMID: 28536273
7. Intravitreal holo-transferrin injection decreased Zip 14 protein levels. These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation. PMID: 28057442
8. ZIP14-mediated zinc transport contributes to regulation of endosomal insulin receptor activity and glucose homeostasis in hepatocytes. PMID: 27703010
9. Results suggest that aberrant zinc distribution observed with Zip14 ablation impacts adipose cytokine production and metabolism, ultimately increasing fat deposition when exposed to endotoxin. PMID: 26646099
10. Slc39a14 deficiency in hemochromatotic mice greatly diminished iron loading of the liver and prevented iron deposition in hepatocytes and pancreatic acinar cells. PMID: 26028554
11. PrP(C) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 via its ferrireductase activity. PMID: 25862412
12. Zinc transporter ZIP14 influences aspects of the pathophysiology of nonlethal polymicrobial murine sepsis induced by cecal ligation/puncture through zinc delivery. PMID: 26272258
13. Oral cadmium chloride administration to ZIP14 knockout mice results in time dependent changes in gene expression. PMID: 25294218
14. ZIP14 is a basolaterally localized protein in enterocytes and is involved in endosomal trafficking of zinc and is necessary for proper maintenance of intestinal tight junctions PMID: 25428902
15. Hepatic ZIP14 protein levels are upregulated in iron-loaded hypotransferrinemic mice. PMID: 23349308
16. We ligated mouse ZIP14A, ZIP14B and ZIP8 cDNA coding regions into the Xenopus-specific vector pXFRM, transcribed these in vitro, and microinjected the capped RNAs into Xenopus oocytes. K(m) and V(max) values for Cd, Zn and Fe uptake were determined. PMID: 23090441
17. Zip14 expression induced by lipopolysaccharides in macrophages attenuates inflammatory response PMID: 23052185
18. The knockdown of ZIP8, ZIP14 or DMT1 by siRNA transfection significantly reduced the uptake of Cd(2+) and Mn(2+) from the apical membrane. PMID: 22534978
19. This study found that Zip14 is capable of mediating cellular uptake of nontransferrin-bound iron characteristic of iron-overload conditions. PMID: 21653899
20. data highlight SLC39A14 as an important novel player in GPCR-mediated signaling PMID: 21445361
21. These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism. PMID: 20682781
22. SLC39A14 plays a role as a zinc transporter during the early stages of adipogenesis PMID: 15794747
23. Zip14 expression is up-regulated through IL-6 PMID: 15863613
24. Zip14 can mediate the uptake of zinc and non-transferrin-bound iron into cells. PMID: 16950869
25. The present study provides the complete characterization of Slc39a14 gene and its ZIP14 mRNAs and proteins and for the first time demonstrates the significance of ZIP14 in Cd2+-mediated cell damage. PMID: 18270315
26. These results suggest that signaling pathways activated by nitric oxide are factors in the upregulation of Zip14, which in turn mediates hepatic zinc accumulation and hypozincemia during inflammation and sepsis. PMID: 19179618

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KEGG: mmu:213053

STRING: 10090.ENSMUSP00000022688

UniGene: Mm.270647