Recombinant Rat D (1B) dopamine receptor (Drd5)

Code CSB-CF007182RA
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Uniprot No.
Alternative Names
Drd5; D(1B dopamine receptor; D(5 dopamine receptor; Dopamine D5 receptor
Rattus norvegicus (Rat)
Expression Region
Target Protein Sequence
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene References into Functions
  1. Findings suggest that activation of dopamine D1/5 receptors alone is sufficient to modify stimulus-induced BOLD responses in the right hippocampus and the history of previous stimulations crucially affects the impact of dopamine receptor activation on stimulus-induced BOLD responses. PMID: 28259782
  2. The results suggest that dopamine receptors in the retinal cells might actively respond to the environmental lighting to act as an important player in the activation of the dopaminergic system in the ocular structures relevant to the lighting-induced pathogenic development of myopia. PMID: 28336436
  3. This study demonstrates, for the first time, that dopamine enhances duodenal permeability of control rat via D5 R PMID: 27652590
  4. the effect of novelty on fear extinction is dependent on dopamine D1 but not D5 receptors in the hippocampus PMID: 25775606
  5. low dopamine D5 receptor density in a well-established animal model for attention-deficit/hyperactivity disorder PMID: 23541742
  6. D1/5 receptor modulates intrinsic mechanisms that amplify a long depolarizing input to sustain spike firing outputs in pyramidal prefrontal cortex neurons. PMID: 23977170
  7. Report involvement of the hippocampal and profrontal cortex dopamine D1/5 receptors in the cognitive effects of reboxetine using the object recognition test in rats. PMID: 23672849
  8. D1/D5 receptor activation facilitates a postsynaptic form of LTP in subicular regular-spiking cells. PMID: 23626827
  9. Transmission at D1/5 receptors mediates the reinstatement of cocaine seeking induced by corticotropin-releasing factor and yohimbine. PMID: 22707255
  10. These data suggest that the regulation of hippocampal long-term depression by the locus coeruleus is supported by D1/D5 receptors PMID: 22038910
  11. quantified the D5 receptor immunoreactivity on the pyramidal cell somas and on spines and dendrites in stratum radiatum and stratum oriens in the hippocampal CA1 region of rats PMID: 21749912
  12. Data show that hippocampal dopamine D1/D5- and beta-adrenergic receptors are specifically required to induce PRP synthesis. PMID: 21768371
  13. Data show that D1/D5 receptor-facilitated long-term potentiation is NMDA receptor-dependent, requires activation of protein kinase A, is presynaptic, and relies on presynaptic Ca(2+) signaling. PMID: 20646048
  14. D5R immunolabeling was mainly in somata and proximal dendrites in the rat medial prefrontal cortex. The density of intradendritic D5R immunolabeling decreased toward the distal regions. PMID: 20226768
  15. these data indicate that a pathway involving D1/D5 receptors and possibly calcyon in the mPFC plays a pivotal role in impulsive choice. PMID: 19690230
  16. The observed differences between D(1) and D(5) can be attributed to structural differences in the C-terminus and its capacity to interact with NMDA receptors and PSD-95. PMID: 19723560
  17. Dopamine receptor D5 is linked to Galpha12- and Galpha13-protein in the nephron. PMID: 12623966
  18. Vascular D1B/D5 receptors inhibit migration of vascular smooth muscle cells, possibly through cyclic AMP activation and the suppression of phospholipase D and protein kinase C activities. PMID: 12688394
  19. D5 dopamine receptor is found to be expressed in the subcommissural organ (SCO), an ependymal brain gland that is located in the roof of the third ventricle. PMID: 15197646
  20. D1/D5R activation in hippocampus initiates intracellular second messenger accumulation, but that this is insufficient to induce an activity-independent long term potentiation PMID: 15328036
  21. Dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength, and these changes are critical factor in acquisition of novel information. PMID: 16855100
  22. results suggest that activation of D1/D5 receptors during memory encoding is necessary for the formation of a persistent memory trace in the hippocampus PMID: 17142305
  23. Agonist receptor activation may have implications for treatment of schizophrenia by opposing hallucinogenic effects. PMID: 17293055
  24. distribution of D1R in the rat basolateral amygdala - there was more prominent D(5) localization to presynaptic structures. The higher affinity of D(5) for dopamine suggests that presynaptic actions may predominate in the BLA at low levels of dopamine. PMID: 19669160

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.
Database Links
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