Recombinant Rat Long-chain fatty acid transport protein 1(Slc27a1)

Code CSB-CF021533RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P97849
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Rattus norvegicus (Rat)
Sequence MRTPGAGTASVASLGLLWLLGLPWTWSAAAAFGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPRIFQAVAQRQPERLALVDASSGICWTFAQLDTYSNAVANLFLQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESVLPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRANDVLYDCLPLYHSAGNIMGVGQCIIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVERRHRVRLAVGNGLRPAIWEEFTQGFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSQGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKSGMAAIADPHNQLDPNSMYQELQKVLASYAQPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYLPLDERVHARICAGDFSL
Source in vitro E.coli expression system
Gene Names Slc27a1
Protein Names Recommended name: Long-chain fatty acid transport protein 1 Short name= FATP-1 Short name= Fatty acid transport protein 1 EC= 6.2.1.- Alternative name(s): Solute carrier family 27 member 1
Expression Region 1-646
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
Subcellular Location Cell membrane, Single-pass membrane protein, Endomembrane system, Single-pass membrane protein, Cytoplasm
Protein Families ATP-dependent AMP-binding enzyme family
Database Links

STRING: 10116.ENSRNOP00000024659

UniGene: Rn.1047

Pathway PPAR signaling pathway
Myocardial Fatty Acid Metabolism

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