Recombinant Rat Mu-type opioid receptor (Oprm1)

1. Study found that early life repetitive procedures, whether tactile or noxious, do affect the intensity of OPRM1-immunoreactivity in the superficial spinal cord dorsal horn after injury in adulthood, without affecting baseline expression. PMID: 29473323
2. HDAC2 expression was upregulated during the course of chronic pancreatitis pain induction, while muopioid receptor activity in the thoracic spinal dorsal horn was significantly suppressed. PMID: 29257262
3. results provide further evidence for the role of accumbens shell mu-opioid receptors but not kappa-opioid receptors in mediating reinforcing e ff ects of EtOH and in regulating EtOH consumption. PMID: 27508965
4. Oprm1 expression and function are higher in the NAc of sedentary rats selectively bred rats for high voluntary running behavior than rats selectively bred rats for low voluntary running behavior. Findings suggest that inherent differences in Oprm1 action and downstream dopaminergic signaling may influence inherited physical activity behavior. PMID: 27743985
5. Study demonstrates that in the rat model, endometriosis can be associated with a decrease in mu opioid receptors (MOR)immunoreactivity within neuronal compartments in addition to a shift in MOR and N-methyl-d-aspartate subunit receptor (NR1) receptor expression within the ventral periaqueductal gray. PMID: 27089914
6. Results suggest that mu opioid receptor-induced suppression of excitatory propagation in the insular cortex is an underlying mechanism of the powerful analgesic effects of mu opioid receptor agonists. In contrast, delta opioid receptors may play a minor role in suppressing acute pain. PMID: 27246300
7. The findings provide evidence for the existence of MOR on the cell membrane, sarcoplasmatic reticulum and mitochondria in left ventricular cardiomyocytes in rats. However, heart failure does not result in an altered expression of the cardiac MOR-opioid system. PMID: 26686371
8. Data show that preconception exposure of morphine to female adolescent animals affects their offspring's response to morphine in a sex-specific manner, which may be mediated in part by differential expression of the mu opioid receptor in the nucleus accumbens and ventral tegmental area. PMID: 26700246
9. findings indicate that G9a contributes critically to transcriptional repression of MORs in primary sensory neurons in neuropathic pain. G9a inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic pain. PMID: 26917724
10. Results suggested that the high nightly voluntary running distance expressed by female rats selectively bred for running motivation is mediated by increased endogenous mu-opioid receptor signaling in the nucleus accumbens PMID: 26044640
11. Activation of the mu opioid receptor (MOR) causes GTP to bind to and to activate Go (alphaobetagamma) PMID: 26119705
12. Smaller cardiovascular responses to stimulation of m1-opioid receptors by endomorphin-2 can be explained by lower expression of M1OR mRNA in the Medial Ncleus sSlitarius of Spontaneously Hypertensive Rats compared to Wistar Kyoto rats. PMID: 25051156
13. mu-opioid and 5-HT1A receptors cooperatively act to regulate escape behaviour. PMID: 25315826
14. K303. in the mu opioid (MOP) receptor is important in conferring selectivity for covalent binding of beta-funaltrexamine PMID: 25481857
15. Study demonstrated that OPRM1 activation attenuated Abeta oligomers-induced neurotoxicity in primary cultured cortical neurons through mTOR signaling PMID: 25146548
16. The results of this study suggested that upregulation of VTA MOR is necessary for the behavioral and biochemical changes induced by social defeat stress. PMID: 25446676
17. This study demonistrated that EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn. PMID: 24718557
18. These results suggest a synergic interaction between the 5-HT1A and the mu-opioid receptor at post-synaptic level on neurons of the dorsal periaqueductal grey that regulate proximal defense, theoretically related to panic attacks. PMID: 23598399
19. Our data demonstrate that mu-delta heteromer signaling does not desensitize and is regulated differently from mu- and delta-receptor signaling following prolonged morphine treatment. PMID: 24976397
20. testosterone plays a key role in the regulation of mu-opioid receptor in trigeminal ganglia under inflammatory conditions PMID: 23801566
21. Fever induced by HIV-glycoprotein 120 is regulated by mu-type opioid receptors. PMID: 24120859
22. Data indicate 3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130) as a selective, and G protein biased mu opioid receptor agonist. PMID: 24063433
23. the association of FKBP12 with OPRM1 attenuates the phosphorylation of the receptor and triggers the recruitment and activation of PKCepsilon. PMID: 24113748
24. Endomorphin 2 and mu-opioid receptor might be involved in both the homeostatic control and information transmission of micturition. PMID: 23671582
25. Reduction of mu opioid receptor signaling attenuates cocaine and heroin seeking behavior. PMID: 23299095
26. The truncated single transmembrane variants can dimerize with the full-length 7-TM mu-opioid receptor (MOR-1) in the endoplasmic reticulum, leading to increased expression of MOR-1 at the protein level. PMID: 23760268
27. results implicate mu-opiate receptors s in the central nucleus of the amygdala in a positive regulation of sodium intake PMID: 23270855
28. Activation of both mu and delta opioid receptors relieves both heat-induced and mechanically induced pain. PMID: 23843537
29. miR-134 participated in inflammatory pain by balancing the expression of MOR1 in dorsal root ganglia PMID: 22865422
30. Activated mu-opioid receptors are at least partly capable of turning pulmonary C-fiber-mediated, rapid-shallow breathing into an apneic state. PMID: 22796630
31. A fragment flanking the 5'-end of the GABArho1 gene suffices to drive transcription in the inner nuclear layer of the retina during early postnatal development. PMID: 23106126
32. In high drinking animals, the anticipation of ethanol is characterized by distinct behaviors, increased exploration and novelty-seeking, and by a specific neurochemical phenotype, greater expression of ENK and MOR within the medial prefrontal cortex. PMID: 22703995
33. These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. PMID: 22732447
34. Suggest that opioids acting on mu-receptors in the rostral medullary raphe exert an excitatory modulation of hyperventilation induced by hypoxia. PMID: 21827637
35. Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward PMID: 22210742
36. A subset of rostral ventromedial medulla neurons expressing mu-opioid receptors contributes to the maintenance of thermal hyperalgesia in neuropathic pain. PMID: 21238509
37. Mu opioid receptor activation has profound effects on the temporal integration between two primary excitatory pathways in CA1 hippocampal region. PMID: 21056047
38. chronic ethanol drinking alters the ability of MOR to endocytose in response to opioid peptides, and consequently, promotes tolerance to the effects of opioids PMID: 21602922
39. MOR was expressed in rat brain neostriatum in both the marginal division as well as in patches, but with different morphological characteristics. These differences in MOR immunoreactivity indicated potential functional differences between them. PMID: 21631922
40. Activation of mu-opioid receptors in nucleus accumbens shell increased feeding on a sweetened-fat diet. PMID: 20562021
41. mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals. PMID: 21543633
42. The identification of the rat exon 11 and its associated variants further demonstrated conservation of 5' splicing in OPRM1 genes among rodents and humans. PMID: 21255438
43. Data suggest that multiple reproductive experiences influence both gene activity and kappa, mu, and delta opioid receptor expression in the periaqueductal gray. PMID: 20574683
44. Glycosylation at the N53 site of the rat mu-opioid receptor does not influence the function of this receptor significantly. PMID: 20592872
45. These findings demonstrate that delta-opioid receptor activation selectively inhibits inputs activated by icilin, whereas mu-opioid receptor activation has a more widespread effect on synaptic inputs to neurons in the superficial dorsal horn. PMID: 20977770
46. Spinal cord MOR/KOR heterodimers represent a unique pharmacological target for female-specific pain control. PMID: 21041644
47. Results suggest that modulation of the delta-opioid receptor 2, but not mu receptor, expression and its synaptic localization may constitute a viable therapeutic approach to disrupt morphine-induced conditioned responses. PMID: 20626460
48. Data show that mu and kappa opioid receptors are expressed as mRNA and translated into specific receptor proteins on cardiac parasympathetic, sympathetic, and sensory neurons as potential binding sites for opioids. PMID: 20653037
49. Coexistence of delta-opioid receptors and mu-opioid receptors in small dorsal root ganglia neurons is a basis for direct interaction of opioid receptors in modulation of nociceptive afferent transmission and opioid analgesia. PMID: 20615975
50. These results suggest that in rat sphenopalatine ganglion neurons activation of M2 mAChR likely modulates mu (micro) opioid receptors transmission in the brain vasculature to adequately maintain cerebral blood flow. PMID: 19889856

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KEGG: rno:25601

STRING: 10116.ENSRNOP00000051290

UniGene: Rn.10118