C1S (riliprubart Biosimilar) Recombinant Monoclonal Antibody

1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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HGNC: 1247

OMIM: 120580

KEGG: hsa:716

STRING: 9606.ENSP00000328173

UniGene: Hs.458355