C1S

C1S, originating in the human liver, is a pivotal element of the plasma complement system. As a serine protease, C1S possesses enzymatic capabilities that are integral to the classical pathway of complement activation. The process begins with the binding of the antigen-antibody complex to C1q, which then triggers the activation of C1r and C1s, culminating in the formation of the C1qr2s2 complex. This initiation sets off a cascade of reactions that can lead to inflammation. C1S is essential in the immune system, contributing not only to the structure of the complement system but also to the modulation of immune responses and inflammation. Investigating C1S deepens our comprehension of the complement system's functions and its association with various diseases, laying a foundation for the development of preventative and therapeutic strategies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

C1S Recombinant Monoclonal Antibody (CSB-RA003657MA1HU)

Validated Data

IHC image of CSB-RA003657MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.

Human Complement C1s subcomponent(C1S) ELISA kit (CSB-EL003657HU)

Validated Data

Code: CSB-EL003657HU

Size: 96T,5×96T,10×96T

Sensitivity: 6.25 ng/mL

Detection Range: 25 ng/mL-1600 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following C1S reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

C1S Antibodies

C1S Proteins

C1S ELISA Kits

C1S Antibodies

C1S Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA003657GA01HU	C1S Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA145542	C1S Antibody	Human	ELISA,WB,IHC
CSB-PA000017	Cleaved-C1S (R437) Antibody	Human	WB, ELISA
CSB-PA060002	C1S Antibody	Human	WB, IHC, ELISA
CSB-PA003657LA01HU	C1S Antibody	Human	ELISA, IHC
CSB-PA003657LB01HU	C1S Antibody, HRP conjugated	Human	ELISA
CSB-PA003657LD01HU	C1S Antibody, Biotin conjugated	Human	ELISA
CSB-RA003657MA1HU	C1S Recombinant Monoclonal Antibody	Human	ELISA, IHC

C1S Proteins

C1S Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP003657HU CSB-BP003657HU CSB-MP003657HU CSB-EP003657HU-B	Recombinant Human Complement C1s subcomponent (C1S)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP003657HU	Recombinant Human Complement C1s subcomponent (C1S)	E.coli

C1S Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP608562BO CSB-EP608562BO CSB-BP608562BO CSB-MP608562BO CSB-EP608562BO-B	Recombinant Bovine Complement C1s subcomponent (C1S), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C1S Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP754200RA CSB-EP754200RA CSB-BP754200RA CSB-MP754200RA CSB-EP754200RA-B	Recombinant Rat Complement C1s subcomponent (C1s)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C1S ELISA Kit

C1S ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL003657HU	Human Complement C1s subcomponent(C1S) ELISA kit	serum, plasma, tissue homogenates	6.25 ng/mL

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C1S

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