CSF1 (Lacnotuzumab Biosimilar) Recombinant Monoclonal Antibody

1. our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID: 30228024
2. Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID: 29991129
3. HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
4. HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID: 27081081
5. Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID: 27573865
6. oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID: 27574949
7. HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID: 26310814
8. Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID: 26046583
9. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID: 25725483
10. HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
11. HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID: 22907429
12. Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID: 23581417
13. HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID: 22896703
14. These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID: 21683083
15. proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID: 15637592
16. HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID: 17488478

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HGNC: 5128

OMIM: 142972

KEGG: hsa:3223

STRING: 9606.ENSP00000243108

UniGene: Hs.549040