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GPR20 (US10906974 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA860774MB1HU
Size US$9799
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Product Details

Uniprot No.
Q99678
Target Names
GPR20
Alternative Names
G protein coupled receptor 20 antibody; G-protein coupled receptor 20 antibody; Gpr20 antibody; GPR20_HUMAN antibody
Species Reactivity
Human
Immunogen
Recombinant Human GPR20 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to the reference antibody described in US10906974, specifically targeting GPR20 (G protein-coupled receptor 20). GPR20 is an orphan G protein-coupled receptor whose endogenous ligand and complete physiological functions remain largely uncharacterized. This receptor is predominantly expressed in the central nervous system, particularly in brain regions including the striatum and hypothalamus, suggesting potential roles in neurological signaling and neuroendocrine regulation. Emerging evidence indicates that GPR20 may be involved in various pathophysiological processes, making it a target of interest for neuroscience research and the investigation of neurological disorders.

The reference antibody patent US10906974 provides the framework for this biosimilar development, ensuring consistent targeting specificity for GPR20. This antibody serves as a valuable research tool for investigating GPR20 expression patterns, cellular localization, and functional characterization in various experimental models. It supports studies aimed at elucidating the orphan receptor's biological role and potential therapeutic relevance in neurological research contexts.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

GPR20 Antibodies

GPR20 Proteins

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Target Background

Function
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Gene References into Functions
  1. GPR20 constitutively activates G(i) proteins without ligand stimulation PMID: 18347022
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
Database Links

HGNC: 4475

OMIM: 601908

KEGG: hsa:2843

STRING: 9606.ENSP00000366970

UniGene: Hs.152432

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