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GPRC5D (SAR-446523 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA882153MB2HU
Size US$9799
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Product Details

Uniprot No.
Q9NZD1
Target Names
GPRC5D
Alternative Names
SAR446523 research-grade biosimilar; SAR 446523 research-grade biosimilar ;GPRC5D antibody; G-protein coupled receptor family C group 5 member D antibody
Species Reactivity
Human
Immunogen
Recombinant Human GPRC5D protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to SAR-446523, targeting GPRC5D (G protein-coupled receptor class C group 5 member D). GPRC5D is an orphan G protein-coupled receptor predominantly expressed on plasma cells and malignant plasma cells in multiple myeloma, with minimal expression on normal tissues. This restricted expression pattern makes GPRC5D an attractive therapeutic target for hematological malignancies. The receptor plays a role in cellular signaling pathways, and its overexpression in multiple myeloma cells has been associated with disease progression and poor prognosis.

SAR-446523 (also known as talquetamab) is a bispecific T-cell engager antibody that redirects T cells to eliminate GPRC5D-expressing cells and has shown promising clinical activity in relapsed/refractory multiple myeloma. This biosimilar antibody provides researchers with a valuable tool for investigating GPRC5D biology, studying plasma cell differentiation, exploring novel immunotherapeutic mechanisms, and developing targeted approaches for multiple myeloma research. It supports preclinical studies aimed at understanding GPRC5D-mediated signaling and evaluating therapeutic strategies in oncology research.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Target Background

Gene References into Functions
  1. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies. PMID: 23510526
  2. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. PMID: 22591013
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscl
Database Links

HGNC: 13310

OMIM: 607437

KEGG: hsa:55507

STRING: 9606.ENSP00000228887

UniGene: Hs.644599

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  Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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