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GPRC5D (Talquetamab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA882153MB1HU
Size US$9799
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Product Details

Uniprot No.
Q9NZD1
Target Names
GPRC5D
Alternative Names
GPRC5D; G-protein coupled receptor family C group 5 member D
Species Reactivity
Human
Immunogen
Recombinant Human GPRC5D protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is a research-grade biosimilar to talquetamab, designed to specifically target G protein-coupled receptor class C group 5 member D (GPRC5D). GPRC5D is an orphan receptor predominantly expressed on the surface of plasma cells and malignant plasma cells in multiple myeloma, while showing limited expression in normal tissues. This restricted expression pattern makes GPRC5D an attractive therapeutic target for hematological malignancies. The receptor plays a role in cellular signaling pathways, and its overexpression in multiple myeloma cells has been associated with disease progression and poor prognosis.

Talquetamab is a bispecific T-cell engager antibody that has demonstrated significant clinical efficacy in relapsed or refractory multiple myeloma by redirecting T cells to eliminate GPRC5D-expressing malignant cells. This biosimilar antibody serves as a valuable research tool for investigating GPRC5D biology, understanding mechanisms of action in multiple myeloma pathogenesis, evaluating immune-mediated cytotoxicity, and supporting preclinical studies in oncology and immunotherapy development. It enables researchers to explore novel therapeutic strategies targeting plasma cell disorders.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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GPRC5D Antibodies

GPRC5D Proteins

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Target Background

Gene References into Functions
  1. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies. PMID: 23510526
  2. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. PMID: 22591013
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscl
Database Links

HGNC: 13310

OMIM: 607437

KEGG: hsa:55507

STRING: 9606.ENSP00000228887

UniGene: Hs.644599

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  Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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