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ICOSLG (Prezalumab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA010958MB1HU
Size US$199
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Product Details

Uniprot No.
O75144
Target Names
ICOSLG
Alternative Names
AMG-557 research-grade biosimilar; AMG-557/MEDI5872 research-grade biosimilar; Anti-B7RP1-MAb research-grade biosimilar; B7RP-1 MAB research-grade biosimilar; MEDI-5872 research-grade biosimilar; ICOSLG antibody; B7H2 antibody; B7RP1 antibody; ICOSL antibody; KIAA0653 antibody;ICOS ligand antibody; B7 homolog 2 antibody; B7-H2 antibody; B7-like protein Gl50 antibody; B7-related protein 1 antibody; B7RP-1 antibody; CD antigen CD275 antibody
Species Reactivity
Human
Immunogen
Recombinant Human ICOSLG protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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ICOSLG Proteins

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Customer Reviews and Q&A

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Target Background

Function
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, BTN/MOG family
Tissue Specificity
Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leuko
Database Links

HGNC: 17087

OMIM: 605717

KEGG: hsa:102723996

STRING: 9606.ENSP00000384432

UniGene: Hs.14155

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  Email: [email protected]
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Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Email
[email protected]
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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