ICOSLG (Inducible T-cell COStimulator Ligand), also known as B7-H2 or CD275, is an immune checkpoint molecule transmembrane protein typically expressed by antigen-presenting cells such as dendritic cells and B cells. Its molecular structure includes an Ig-like V-type domain, responsible for binding to its receptor ICOS, as well as a transmembrane region and an intracellular domain. The interaction between ICOSLG and its receptor ICOS plays a crucial role in the immune system.When ICOSLG binds to ICOS, it promotes the activation and proliferation of T cells, as well as antibody production by B cells. This is essential for regulating immune responses and maintaining immune balance. The activation of ICOSLG can also influence the generation of regulatory T cells, which has significant implications for immune tolerance and the control of autoimmune diseases. In cancer therapy, inhibiting the ICOSLG-ICOS interaction may help enhance T cell immune responses against tumors. Additionally, antagonists (inhibitors) of ICOSLG are being researched for the treatment of autoimmune diseases, as they can reduce abnormal immune activity. ICOSLG is an important target in cancer immunotherapy and the treatment of autoimmune diseases.
Recombinant Human ICOS ligand(ICOSLG),partial (Active) CSB-MP010958HU1
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml.
The following ICOSLG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ICOSLG Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA010958GA01HU | ICOSLG Antibody |
Human | ELISA,WB |
CSB-PA010958ESR1HU | ICOSLG Antibody |
Human | ELISA, IHC |
CSB-PA279895 | ICOSLG Antibody |
Human | ELISA,IHC |
CSB-PA924853 | ICOSLG Antibody |
Human | ELISA,WB |
ICOSLG Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF010958HU | Recombinant Human ICOS ligand (ICOSLG) |
in vitro E.coli expression system |
CSB-YP010958HU1 CSB-EP010958HU1 CSB-BP010958HU1 CSB-EP010958HU1-B |
Recombinant Human ICOS ligand (ICOSLG), partial |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP010958HU1 | Recombinant Human ICOS ligand (ICOSLG), partial (Active) |
Mammalian cell |
ICOSLG ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL010958HU | Human ICOS ligand(ICOSLG) ELISA kit |
serum, plasma, tissue homogenates | 23.4 pg/mL |