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LRRC15 (Samrotamab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA819484MB1HU
Size US$9799
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Product Details

Uniprot No.
Q8TF66
Target Names
LRRC15
Alternative Names
Leucine-rich repeat-containing protein 15；Leucine-rich repeat protein induced by beta-amyloid homolog；hLib , LRRC15, LIB
Species Reactivity
Human
Immunogen
Recombinant Human LRRC15 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to Samrotamab, targeting leucine-rich repeat-containing protein 15 (LRRC15). LRRC15 is a transmembrane protein highly expressed on cancer-associated fibroblasts (CAFs) within the tumor microenvironment across multiple solid tumor types. This protein plays a critical role in extracellular matrix remodeling and is associated with immunosuppressive stromal responses, making it an attractive target for cancer therapy. LRRC15 expression correlates with poor prognosis in various malignancies, including soft tissue sarcoma, breast cancer, and non-small cell lung cancer, as its presence on CAFs contributes to tumor progression and therapeutic resistance.

Samrotamab is an investigational antibody-drug conjugate designed to selectively target LRRC15-expressing stromal cells while sparing normal tissues. This biosimilar antibody serves as a valuable research tool for investigating LRRC15 biology, studying tumor-stroma interactions, and exploring novel therapeutic strategies targeting the tumor microenvironment. It enables researchers to examine CAF-mediated mechanisms of cancer progression and evaluate potential stromal-directed interventions in preclinical models.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

LRRC15 Antibodies

LRRC15 Proteins

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Target Background

Gene References into Functions
  1. LRRC15 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  2. Lib may contribute to regulation of cell-matrix adhesion interactions with respect to astrocyte recruitment around senile plaques in Alzheimer's disease brain PMID: 16098915
  3. Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy are presented. PMID: 18385238
  4. LRRC15 is induced by EWS-WT1(+KTS) in the tumor DSRCT and may play a role in cellular invasion. PMID: 12923058
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Brain and placenta.
Database Links

HGNC: 20818

KEGG: hsa:131578

STRING: 9606.ENSP00000389128

UniGene: Hs.288467

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